Results 61 to 70 of about 2,112,509 (301)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Corporate values guiding the world's largest family-owned businesses: A comparison with non-family firms [PDF]

open access: yes
This paper analyzes formally stated corporate values, a key topic of concern in the field of family businesses. More specifically, the study aims to contribute to the literature by enabling a deeper understanding of the differences and similarities of ...
Tapies, Josep, Ceja, Lucia
core  

Intergenerational transmission of traditional family values among the Turkic-speaking peoples of Dagestan

open access: yesИсторическая этнология
The article is devoted to the study of the system of traditional family values among the Turkic-speaking peoples living in the lowland part of Dagestan.
Madina B. Gimbatova
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Necropolitics of Russia’s Traditional Family Values

open access: yes, 2022
This article argues that child protection rhetoric rarely applies to all children and that it, in fact, often contains decisions over whose lives are worthy of protection, and whose are not.
Brock, Maria, Brock, Maria,
core   +1 more source

Family values and well-being of adolescents in two-parent and divorced Russian families: A study in a small town and a metropolis

open access: yesRUDN journal of Sociology
The article considers family values and subjective well-being of adolescents in divorced and two-parent families, based on the survey of 14-17-year-olds in Saint Petersburg and the city of Tosno in the Leningrad Region. The study showed that adolescents’
O. N. Bezrukova, V. A. Samoylova
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Values and longevity in family business: Evidence from a cross-cultural analysis [PDF]

open access: yes
The link between longevity and values has been pointed out by several authors, who have underlined values as an important factor for supporting a long-term vision, as well as a source of competitive advantage based on using values as specific company ...
Fernandez, Maria, Tapies, Josep
core  

The conceptual foundations of traditions and value relations in the Russian family

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки
Importance. Society is witnessing a shift in models of family relations, a growing popularity of interests outside the family, and a deepening problem of intergenerational understanding.
T. E. Bezruchenko
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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