Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Unemployment and well-being in Europe. The effect of country unemployment rate, work ethics and family ties [PDF]
Subjective well-being literature shows that higher unemployment rate corresponds to lower psychological cost of own unemployment. The goal of the paper is to deepen the understanding of this regularity by investigating the role played by the work ethics ...
MIKUCKA Malgorzata
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Libido-sexual disorders and abandonment of injectable contraceptives among users of the Ivorian Association for Family Well-Being in Korhogo, Côte d'Ivoire. [PDF]
Front Glob Womens Health, 2023 Essis EM +9 more
europepmc +1 more source
Falling Through the Cracks: The Impact of Immigration Enforcement on Children Caught Up in the Child Welfare System [PDF]
, 2012 This paper outlines the unique challenges that federal and state immigration enforcement measures pose to child well-being and family unity, including the implications for children and families involved in the child welfare ...
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Family Well-Being During the COVID-19 Pandemic: The Risks of Financial Insecurity and Coping. [PDF]
J Res Adolesc, 2023 Gonzalez MR +15 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Parenting and pandemic pressures: Examining nuances in parent, child, and family well-being concerns during COVID-19 in a Canadian sample. [PDF]
Front Epidemiol, 2023 Colucci L, Smith JA, Browne DT.
europepmc +1 more source
Economic Well-Being and Child Labor: The Inter action of Family and Industry [PDF]
How did industrialization in the nineteenth century affect the well-being of children among American working class families? Two revealing surveys from 1890 and 1907 are used to examine the implications of child labor on schooling decisions and on ...
Claudia D. Goldin, Donald O. Parsons
core