Results 51 to 60 of about 2,169,555 (268)

The CATCH curricula fostered their successful implementation in early childhood and K-12 education by integrating interactive learning, culturally responsive programming, and parental engagement

Discover Public Health
Early childhood and K-12 education play an important role in shaping health behaviors among young children, thereby establishing a foundation for lifelong wellness. This qualitative study evaluates the implementation of the CATCH (Coordinated Approach to
Alina I. Palimaru, Mallika Bhandarkar, Andrea S. Richardson, Julia I. Caldwell, Keisha M. Macon, Dipa Shah, Tony Kuo   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Relationship between cognitive performance and postural sway characteristics in community-dwelling older japanese adults: findings from the DOSANCO health study

Archives of Gerontology and Geriatrics Plus
Objectives: Cognitive function plays a critical role in postural control, yet its association with postural sway remains incompletely understood. This study examined the association between cognitive function and postural stability among community ...
Shigekazu Ukawa, Sachiko Sasaki, Emiko Okada, Wenjing Zhao, Takafumi Nakagawa, Akihiro Imae, Koshi Nakamura, Akiko Tamakoshi   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Family relationships: A long-lasting source of well-being

Community Psychology in Global Perspective, 2016
This article examines the link between family relationships and well-being, focusing on relationship quality, as well as on the positive and negative constructs used to describe it.
Eugenia Scabini
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

KELENTINGAN KELUARGA, DUKUNGAN SOSIAL, DAN KESEJAHTERAAN KELUARGA NELAYAN JURAGAN DAN BURUH DI DAERAH RAWAN BENCANA

Jurnal Ilmu Keluarga dan Konsumen, 2011
Abstrak Tujuan penelitian ini adalah untuk menganalisis perbedaan kelentingan keluarga, dukungan sosial, dan kesejahteraan keluarga antara nelayan juragan dan buruh di daerah rawan bencana; menganalisis hubungan antar peubah-peubah tersebut, dan ...
Euis Sunarti, Rahma Nur Praptiwi, Istiqlaliyah Muflikhati   +2 more
doaj   +1 more source