Results 41 to 50 of about 13,148,849 (278)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Use of fan rig data for the understanding and prediction of fan broadband noise and noise changes due to a variable area nozzle

open access: yes, 2009
This thesis presents the results of the research component of this EngD, entitledUse of fan rig data for the understanding and prediction of fan broadband noise and noisechanges due to a variable area nozzleAs suggested by the title, fan rig noise ...
Deane, Eugene Pio
core   +1 more source

Building disability fan studies

open access: yesTransformative Works and Cultures
[0.1] Abstract—Editorial for "Disability and Fandom," guest edited by Olivia Johnston Riley and Lauren Rouse, special issue, Transformative Works and Cultures, no. 48 (June 15, 2026).
Olivia Johnston Riley, Lauren Rouse
doaj   +1 more source

Roundtable with Paul Booth, Melissa A. Click, and Suzanne Scott

open access: yesTransformative Works and Cultures, 2018
Roundtable with Paul Booth, Melissa A. Click, and Suzanne Scott. Melissa A. Click and Suzanne Scott, eds. 2018. The Routledge Companion to Media Fandom. New York: Routledge. Paul Booth, ed. 2018. A Companion to Media Fandom and Fan Studies.
Louisa Ellen Stein
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Animal fans: Toward a multispecies fan studies

open access: yesTransformative Works and Cultures, 2019
In an exploration of the potential for (and implications of) animal fans—not human fans of animals but nonhuman animals as fans—situated in ongoing debates about the personhood of nonhuman species, I suggest ways that the animal turn taking place in the humanities and social sciences might affect fan studies.
openaire   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

On the Ky Fan Inequality [PDF]

open access: yes, 2001
Some inequalities related to the Ky Fan and C.-L.
Dragomir, Sever S   +1 more
core   +5 more sources

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