Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023 Pancytopenia is a reduction in all the three peripheral blood cell lineages and presents as anemia, leukopenia, and thrombocytopenia. Aplastic anemia is pancytopenia with bone marrow hypocellularity.
Manaswini Edara +3 more
doaj +1 more source
Anesthesia for a patient with Fanconi anemia for developmental dislocation of the hip: a case report
Brazilian Journal of Anesthesiology, 2014 Fanconi anemia is a rare autosomal recessive inherited bone marrow failure syndrome with congenital and hematological abnormalities. Literature regarding the anesthetic management in these patients is limited.
Zafer Dogan +4 more
doaj +3 more sources
Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers [PDF]
, 2015 PURPOSE: Fanconi anemia is an inherited disorder associated with a constitutional defect in the Fanconi anemia DNA repair machinery that is essential for resolution of DNA interstrand crosslinks.
Andreassen, Paul R. +11 more
core +1 more source
Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector. [PDF]
, 2010 One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA damage during ex vivo culture and manipulation.
Adair, J +10 more
core +5 more sources
Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]
, 2016 Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis +7 more
core +3 more sources
Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]
, 2012 © 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Guc-Scekic, M +11 more
core +3 more sources
Diagnosis of Fanconi anemia in patients with bone marrow failure
Haematologica, 2009 Background Patients with bone marrow failure and undiagnosed underlying Fanconi anemia may experience major toxicity if given standard-dose conditioning regimens for hematopoietic stem cell transplant.
Fernando O. Pinto +12 more
doaj +1 more source
Preventing hereditary cancers caused by opportunistic carcinogens [PDF]
, 2011 Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
core +2 more sources
Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5′ flap DNA: basis of interstrand cross-link repair by FAN1 [PDF]
, 2014 Fanconi anemia (FA) is an autosomal recessive genetic disorder caused by defects in any of 15 FA genes responsible for processing DNA interstrand cross-links (ICLs).
Carr, Antony +10 more
core +1 more source
Oral human papillomavirus is common in individuals with Fanconi anemia [PDF]
, 2015 Fanconi anemia is a rare genetic disorder resulting in a loss of function of the Fanconi anemia-related DNA repair pathway. Individuals with Fanconi anemia are predisposed to some cancers, including oropharyngeal and gynecologic cancers, with known ...
Brown, Darron R. +12 more
core +2 more sources