Results 51 to 60 of about 2,262,684 (231)

Inherited mutations impair responses to environmental carcinogens: Cancer prevention in mutation carriers [PDF]

, 2011
Some environmental carcinogens may be responsible for a modest increase in the numbers of cancers after years of exposure. Economic or political factors weigh against widespread bans of carcinogens.
Bernard Friedenson
core   +2 more sources

Fanconi Syndrome and Tenofovir Alafenamide

Annals of Internal Medicine, 2019
TO THE EDITOR: Some issues in Bahr and colleagues' (1) case report on a patient with Fanconi syndrome caused by tenofovir alafenamide (TAF) warrant further investigation.
Hortensia lvarez, J. Llibre
semanticscholar   +1 more source

Aminoaciduria Caused by Fanconi Syndrome in a Heifer

Journal of Veterinary Internal Medicine, 2017
A case study of renal tubular dysfunction consistent with idiopathic Fanconi syndrome is reported in an 18‐month‐old Holstein heifer. The clinical, biochemical, and histopathological features are described.
N. Cesbron, L. Dorso, A.‐L. Royer, G. Dervilly‐Pinel, J. Hervé   +4 more
doaj   +1 more source

CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]

, 2020
The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I, Jacinto, Filipe, Link, Wolfgang   +2 more
core   +1 more source

Fanconi Syndrome: Genetic and Acquired Determinants

Journal of Education, Health and Sport
Fanconi syndrome is a condition characterized by proximal tubular dysfunction of the nephron, leading to urinary loss of glucose, amino acids, and electrolytes such as phosphate, sodium, potassium, calcium, and magnesium. It often co-occurs with tubular
Rafał Rejmak, Kornelia Karamus, Jan Biłogras, Wojciech Urban, Martyna Borowska-Łygan, Konrad Strużek, Jakub Tomaszewski   +6 more
doaj   +1 more source

Fanconi syndrome due to tenofovir disoproxil fumarate reversed by switching to tenofovir alafenamide fumarate in an HIV-infected patient

Therapeutic Advances in Infectious Disease, 2018
A case of tenofovir-induced Fanconi syndrome in a patient receiving antiretroviral therapy for HIV infection, with resolution of the related electrolyte abnormalities upon switch from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate, is ...
Nomvuyo Z. Mothobi, Jeffrey Masters, D. Marriott   +2 more
semanticscholar   +1 more source

Fanconi syndrome with lysinuric protein intolerance

, 2014
We present the case of a 9-year-old child with lysinuric protein intolerance and Fanconi syndrome. She was referred to our hospital with a persistent metabolic acidosis and polyuria. Renal investigations revealed all laboratory signs of Fanconi syndrome,
PISANI, ANTONIO, RICCIO, ELEONORA
core   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process [PDF]

, 2015
International audienceBACKGROUND:The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition.
Azpeitia, Eugenio, Cortes, Edith, Frias, Sara, Garcia-de Teresa, Benilde, Juarez, Ulises, Mendoza, Luis, Ortiz, Rocio, Ostrosky-Wegman, Patricia, Rodriguez, Alfredo, Salazar, Ana M., Sosa, David, Torres, Leda   +11 more
core   +4 more sources

Comparison of Two Strategies of Analysis of Urinary Protein Composition for the Diagnosis and Follow‐Up of Renal Diseases

ELECTROPHORESIS, EarlyView.
ABSTRACT Proteinuria analysis is necessary to detect the early stages of kidney disease before the estimated glomerular filtration rate deteriorates and to monitor the progression of treated kidney disease. Electrophoresis is often the first orientation test, although this test is time‐consuming and its interpretation may be subjective.
Joris Guyon, Jeanne Malaubier, Hong‐Van Pham, Lila Rami Arab, Laurence Pieroni, Marie‐Laure Curutchet‐Burtin, Rémi Segues, Sylvie Caspar‐Bauguil, Annie M. Bérard   +8 more
wiley   +1 more source