Results 191 to 200 of about 1,170,398 (288)

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Han L, Zhang Q, Wu Y, Luo W, Mo S, Fang H, Li Q, Wang R, Cai G, Dai W.   +9 more
europepmc   +1 more source

Centering geospatial data uncertainty and the potential for injustice in pastoralist rangeland conservation prioritization

Conservation Biology, EarlyView.
Abstract Procedural, distributional, recognitional, and epistemic justice aspects of conservation interventions are well documented in contexts where pastoralism is a key livelihood and way of life. Geospatial analyses and representations of wildlife conservation and restoration that are increasingly applied in pastoralist rangeland socioecological ...
Ryan R. Unks
wiley   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis. [PDF]

Adv Sci (Weinh)
Zhang Y, Wang Y, Li B, Li X, Liu C, Chen Y, Tian C, Wang D, Gu X, Jiang C, Wei Y, Ding Q.   +11 more
europepmc   +1 more source

Assessing differences among elasmobranch nurseries to aid conservation based on a genomics framework

Conservation Biology, EarlyView.
Abstract Elasmobranch nurseries often differ in environmental conditions, demographics, and use patterns. These differences affect the distribution of genetic variation among nurseries. However, conservation and management strategies often fail to account for such differences because they are difficult to characterize.
Dominic G. Swift, Amanda M. Barker, William B. Driggers III, Bryan S. Frazier, Douglas H. Adams, James J. Gelsleichter, Dana M. Bethea, Bethany M. Deacy, David S. Portnoy   +8 more
wiley   +1 more source

Revised safety evaluation of the food enzyme catalase from the non-genetically modified <i>Aspergillus niger</i> strain CTS2093. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Andreoli C, Terron A, Criado A, Aguilera J, Andryszkiewicz M, Liu Y.   +18 more
europepmc   +1 more source

Reconsidering the role of introduced species in the climate‐affected and highly invaded eastern Mediterranean

Conservation Biology, EarlyView.
Abstract Bioinvasions are considered mostly as a biodiversity and conservation hazard, but in specific situations, introduced species can bring ecological or socioeconomic benefits. We assessed the social–ecological role of marine introduced species in the eastern Mediterranean Sea—a global hotspot of bioinvasions and extirpations—and their potential ...
Stelios Katsanevakis, Jonathan Belmaker, Gil Rilov, Erez Yeruham, Andreas Konstantinidis, Maria Papazekou, Sylvaine Giakoumi, Antonios D. Mazaris   +7 more
wiley   +1 more source

Microsatellite-based assessment of genetic diversity and inbreeding in the Ukrainian water buffalo (<i>Bubalus bubalis</i>) population. [PDF]

Vet World
Mokhnachova N, Skrepets K, Zhukorskyi O, Starodub L, Ladyka V, Tymchenko O.   +5 more
europepmc   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

Fatty acid oxidation drives acetyl-CoA-dependent H3K9ac reprogramming to promote adaptive resistance to BRAF^V600E inhibition in thyroid cancer. [PDF]

Cell Death Dis
Wang X, Zhang J, Yuan J, Wen L, Ying T, Xu Z, Zhou Z, Chen S, Zhou Q, Sheng J, Luo C, Teng L, Wang W.   +12 more
europepmc   +1 more source