Results 181 to 190 of about 64,984 (332)

Myofibroblast‐Like CAFs in Metastatic Lymph Nodes Drive Tumor Stemness and Poor Prognosis in Head and Neck Cancer

Cancer Science, EarlyView.
Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hiroyuki Hagiwara, Hideyuki Takahashi, Reika Kawabata‐Iwakawa, Miho Uchida, Hiroe Tada, Toshiyuki Matsuyama, Masaomi Motegi, Yuichi Tomidokoro, Kazuaki Chikamatsu   +8 more
wiley   +1 more source

Intensive Endoscopic Resection for Downstaging of Superficial Non-ampullary Duodenal Epithelial Tumor Burden in Familial Adenomatous Polyposis: A Single-center Retrospective Study on Long-term Clinical Outcome. [PDF]

DEN Open
ABSTRACT Background and Study Aims Familial adenomatous polyposis (FAP) is a genetic condition that increases the risk of developing colorectal polyposis and cancer, as well as superficial non‐ampullary duodenal epithelial tumors (SNADETs). In this single‐center retrospective study, we investigated the long‐term clinical outcomes of intensive ...
Kawamura R, Yamada M, Takamaru H, Nakajima T, Abe S, Nonaka S, Oda I, Tanabe N, Hirata M, Saito Y.   +9 more
europepmc   +2 more sources

Angiogenic and Stromal Remodeling Associated With Aggressive Fibrosarcomatous Dermatofibrosarcoma Protuberans

Cancer Science, EarlyView.
FS‐DFSP exhibits coordinated angiogenic and stromal remodeling characterized by immature vascular features, CAF accumulation, and enhanced macrophage infiltration. VEGFA, CCL2, and CXCR4 may contribute to this tumor‐promoting microenvironment. ABSTRACT Although collagen type 1 alpha 1 (COL1A1)–platelet‐derived growth factor B‐chain (PDGFB) gene fusion ...
Sakura Shiraishi, Takeshi Iwasaki, Ken Takigawa, Kengo Kawaguchi, Hiroki Sonoda, Kohta Miyawaki, Takumi Tomonaga, Taro Mori, Makoto Endo, Koji Kato, Yasuharu Nakashima, Yoshinao Oda   +11 more
wiley   +1 more source

Normas

InCantare, 2014
Fap fap
doaj   +2 more sources

O afeto nas famílias recompostas: possibilidades de repercussão jurídica positiva do elemento afetivo nas relações de afinidade no Brasil

Civilistica.com, 2019
O presente artigo se propõe a analisar de que formas o afeto pode repercutir nas relações jurídicas decorrentes do parentesco por afinidade. Inicialmente, será verificada a questão do parentesco socioafetivo, demonstrando-se que o reconhecimento deste ...
Nadinne Sales Callou Esmeraldo Paes
doaj  

Peanut‐Specific IgG4 mAbs Promote Regulatory Immune Responses Ex Vivo and Improve Oral Immunotherapy in Mice

Clinical &Experimental Allergy, EarlyView.
Allergen‐specific IgG4 mAbs were shown to block facilitated IgE binding to B cells and redirect allergens towards myeloid APC, leading to increased IL‐10 production in vitro. In combination with oral AIT, the mAbs inhibited mast cell activation and sustained allergen‐specific IgG4 levels in an in vivo model of peanut allergy. ABSTRACT Background Peanut
Pascal Gasser, Alex A. J. Overman, Mojtaba Porbahaie, Chiara Arena, Juliane Konrad, Renate Repke, Sandra Götschi, Dimitri Bieli, Tiziana Sonati, Alcide Barberis, Niccolò Pengo, R. J. Joost van Neerven, Natascha Wuillemin   +12 more
wiley   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Design Considerations for Visualization Transitions of 3D Spatial Data in Hybrid AR‐Desktop Environments

Computer Graphics Forum, EarlyView.
We present design considerations for animated transitions of the appearance of 3D spatial datasets in a hybrid Augmented Reality‐desktop context. Such hybrid interfaces combine both traditional and immersive displays to facilitate the exploration of 2D and 3D data representations in the environment in which they are best displayed.
Yucheng Lu, Tobias Rau, Benjamin Lee, Andreas Köhn, Michael Sedlmair, Christian Sandor, Tobias Isenberg   +6 more
wiley   +1 more source

An activatable fluorescent probe for fibroblast activation protein α and its bioimaging applications. [PDF]

RSC Adv
Feng L, Chen H, Tian Z, Li W, Dang Y, Liang G, Xing C, Shu X, Ning J, Yang F, Ma X.   +10 more
europepmc   +1 more source

Unravelling the phylogeny of armadillos and their kin (Mammalia, Xenarthra, Cingulata) combining morphological, molecular, and stratigraphic data

Cladistics, EarlyView.
Abstract Cingulata, a major lineage of Xenarthra, comprises extinct and extant armoured placental mammals that diversified throughout the Cenozoic. Despite extensive study, phylogenetic hypotheses based on morphological and molecular data remain incongruent, and no total evidence analysis has been conducted. Here, we integrate the largest morphological
Daniel M. Casali, Mariela C. Castro, Martin R. Ciancio, Timothy J. Gaudin, Jeremy L. Bramblett, Alberto Boscaini, Fernando A. Perini, Max C. Langer   +7 more
wiley   +1 more source