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Defining absolute postoperative desmoid risk in familial adenomatous polyposis according to APC genotype and family history: retrospective cohort study. [PDF]

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Zare B, Bahar M, Clark S, Latchford A.
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FAP Upregulates PD-L1 Expression in Cancer-Associated Fibroblasts to Exacerbate T Cells Dysfunction and Suppress Anti-Tumor Immunity

Cancer Letters
FAP-positive cancer-associated fibroblasts (CAFs), recognized as a critical subset of CAFs, have been implicated in fostering an immunosuppressive tumor microenvironment in various cancers.
Rongyuan Wei, Zhenxiong Zhao, Chenchen Liu   +2 more
exaly   +2 more sources

Targeting Fibroblast Activation Protein (FAP): Advances in CAR-T Cell, Antibody, and Vaccine in Cancer Immunotherapy

Drug Delivery and Translational Research, 2023
Leila Arabi
exaly   +2 more sources

Establishment of FAP-overexpressing Cells for FAP-targeted Theranostics

Current Medical Science, 2023
Fibroblast activation protein (FAP) has been widely studied and exploited for its clinical applications. One of the difficulties in interpreting reports of FAP-targeted theranostics is due to the lack of accurate controls, making the results less specific and less confirmative.
Hui-Ru, Jian, Wen-Hao, Niu, Zhuo-Shuo, Xu, Jia-Xu, Zhu, Xin, Pan, Yi-Rui, Zhang, Ping, Lei, Fa-Qing, Huang, Yong, He   +8 more
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Synthesis and Evaluation of 99mTc-Labeled FAP Inhibitors with Different Linkers for Imaging of Fibroblast Activation Proteins in Tumors.

Journal of Medicinal Chemistry, 2023
Fibroblast activation protein (FAP) is a potential target for tumor diagnosis and treatment due to its selective expression on cancer-associated fibroblasts (CAFs) in most solid tumor stroma.
Q. Ruan, Qian-Na Wang, Yu-Hao Jiang, Jun-Hong Feng, Guang-Hua Yin, Jun-Bo Zhang   +5 more
semanticscholar   +1 more source

In vivo FAP-CAR macrophages enhance chemotherapy and immunotherapy against pancreatic cancer by removing the fibrosis barrier.

Journal of Controlled Release
Patients with pancreatic ductal adenocarcinoma (PDAC) derive limited benefits from chemotherapy or immunotherapy, with a five-year survival rate still below 10 %.
Wen-Guang Wang, Kai-Yuan Hu, Jun-Jie Xue, Jing-Yi Chen, Xiuli Du, Tian Zhao, Yiwei Chen, Xin-Ying Tang, Lu Xu, Xin-Bao Hao, Xian-Jing Li, Yong Yang   +11 more
semanticscholar   +1 more source

TGF-β1-activated cancer-associated fibroblasts promote breast cancer invasion, metastasis and epithelial-mesenchymal transition by autophagy or overexpression of FAP-α.

Biochemical Pharmacology, 2021
Cancer-associated fibroblasts (CAFs) play an important role in the initiation, metastasis, and invasion of breast cancer. However, whether autophagy acts as a tumor promotion mechanism by inducing epithelial-mesenchymal transition (EMT) is still ...
Minli Huang, Meng-Ru Fu, Jia Wang, Chun-Hua Xia, Hong Zhang, Yu-Qing Xiong, Jia-Ke He, Jian-Ming Liu, Bingchen Liu, Si-Yi Pan, Fang-Lan Liu   +10 more
semanticscholar   +1 more source

Update on Surgical Management of FAP

Clinics in Colon and Rectal Surgery, 2023
AbstractFamilial adenomatous polyposis (FAP) is an autosomal dominant disease caused by pathogenic germline adenomatous polyposis coli mutation, and characterized with multiple adenomas in the colon and the rectum. Various genetic variants have been confirmed to be associated with corresponding FAP phenotypes, which play important roles in the ...
Tianqi, Zhang, Ye, Xu
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