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Biochemical and Biophysical Research CommunicationsCancer poses a significant risk to human well-being. Among the crucial characteristics of cancer is metabolic reprogramming. To meet the relentless metabolic needs, cancer cells enhance cholesterol metabolism within the adverse tumor microenvironment.
wang guojuan
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FEBS Journal, 2003
Rubber transferase, a cisâprenyltransferase, catalyzes the addition of thousands of isopentenyl diphosphate (IPP) molecules to an allylic diphosphate initiator, such as farnesyl diphosphate (FPP, 1), in the presence of a divalent metal cofactor. In an effort to characterize the catalytic site of rubber transferase, the effects of two types of protein ...
Katrina Cornish +1 more
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Rubber transferase, a cisâprenyltransferase, catalyzes the addition of thousands of isopentenyl diphosphate (IPP) molecules to an allylic diphosphate initiator, such as farnesyl diphosphate (FPP, 1), in the presence of a divalent metal cofactor. In an effort to characterize the catalytic site of rubber transferase, the effects of two types of protein ...
Katrina Cornish +1 more
exaly +3 more sources
A New Class of Highly Potent Farnesyl Diphosphate-Competitive Inhibitors of Farnesyltransferase
Journal of Medicinal Chemistry, 1998T, Aoyama +15 more
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Cocrystal Structure of Protein Farnesyltransferase Complexed with a Farnesyl Diphosphate Substrate,
Biochemistry, 1998Protein farnesyltransferase (FTase) catalyzes the transfer of the hydrophobic farnesyl group from farnesyl diphosphate (FPP) to cellular proteins such as Ras at a cysteine residue near their carboxy-terminus. This process is necessary for the subcellular localization of these proteins to the plasma membrane and is required for the transforming activity
S B, Long, P J, Casey, L S, Beese
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Farnesyl-diphosphate farnesyltransferase
1997Dietmar Schomburg, Dörte Stephan
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Drug Development Research, 1995
AbstractProtein prenylation is increasingly recognized as an important mechanism by which functional association of proteins to membranes is mediated. Ras proteins, regulators of cell proliferation and differentiation, are among the proteins that undergo farnesylation, one of the two prenylation modifications known.
Mariano Barbacid
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AbstractProtein prenylation is increasingly recognized as an important mechanism by which functional association of proteins to membranes is mediated. Ras proteins, regulators of cell proliferation and differentiation, are among the proteins that undergo farnesylation, one of the two prenylation modifications known.
Mariano Barbacid
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Cancer Research, 2013
Abstract Identifying cancer progression associated genes that predicting patient outcome might provide opportunities for developing better therapeutic strategies for lung cancer patients. In the present study, we investigated whether farnesyl diphosphate farnesyltransferase (FDFT1), an enzyme of mevalonate pathway, is a potential ...
Yi-Fang Yang, Yi-Hua Jan, Michael Hsiao
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Abstract Identifying cancer progression associated genes that predicting patient outcome might provide opportunities for developing better therapeutic strategies for lung cancer patients. In the present study, we investigated whether farnesyl diphosphate farnesyltransferase (FDFT1), an enzyme of mevalonate pathway, is a potential ...
Yi-Fang Yang, Yi-Hua Jan, Michael Hsiao
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Cancer Research, 2012
Abstract Lung cancer is the leading cause of the human cancer-related death in the world and non-small cell lung cancer (NSCLC) accounts for up to 80 % of those patients. Cholesterol metabolism is especially active in cancer cells, whereas cholesterol synthesis inhibition has been show to reduce tumor cell growth.
Yi-Fang Yang +4 more
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Abstract Lung cancer is the leading cause of the human cancer-related death in the world and non-small cell lung cancer (NSCLC) accounts for up to 80 % of those patients. Cholesterol metabolism is especially active in cancer cells, whereas cholesterol synthesis inhibition has been show to reduce tumor cell growth.
Yi-Fang Yang +4 more
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