Results 121 to 130 of about 3,100,530 (307)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A study of consumer willingness to adopt two-dimensional anthropometric measurement systems
Frontiers in Computer ScienceOnline shopping has become common, but fitting clothes purchased online remains a challenge for both consumers and merchants. Two digital solutions are available: virtual fitting to try on clothes or using a 2D anthropometric measurement system to select
Lixian Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Extraction of Fiber from Schoenoplectus acutus Plant and Characterization of Its Properties
Advances in Materials Science and EngineeringThis work aims to extract and characterize the fibers from the Schoenoplectus acutus plant and assess their suitability for use as textile fibers. The fibers from Schoenoplectus acutus plants were extracted using alkaline extraction, water retting, and ...
Alemayehu Assefa +2 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Sustainable fibre for sustainable fashion supply chains: where the journey to sustainability begins [PDF]
, 2016 Adopting a sustainable business model is an essential element of gaining competitive advantage. Specifically, the management of fashion and textile supply chains characterized by geographical extension requires paying particular attention to ...
WANKOWICZ, EWA
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Designing a Smart Garment for Dynamic Sitting Reminders
SensorsCurrently, the sedentary nature of office work has led to a steady increase in the prevalence of spinal disorders, including lower back pain, back pain, and neck pain.
Yujie Hou +5 more
doaj +1 more source