Results 151 to 160 of about 1,440,066 (305)
TREX1, a predator for treating MSI‐H tumors?
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Prisunic, la mode et le design : une entreprise face au style, 1945-1972
Sophie Chapdelaine
doaj +1 more source
Microsurgical treatment of sacral spinal dural arteriovenous fistula. [PDF]
Hallak H, Vellimana AK.
europepmc +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
« Créer c’est avoir vu le premier ». Les Galeries Lafayette et la mode (1893-1969)
Florence Brachet-Champsaur
doaj +1 more source
The Intricacy of Consuming Fast-Fashion Clothing: The Role of Guilt and Sustainability Values. [PDF]
Cavazos-Arroyo J, Puente-Díaz R.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Mastectomy Reconstruction Techniques for Gender Diverse Breast Cancer and High Risk Patients: A Case Series and Literature Overview. [PDF]
Calderon T +8 more
europepmc +1 more source

