Results 121 to 130 of about 96,135 (309)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Lamine Badian Kouyaté of Xuly.Bët and Dr. Valerie Steele, director and chief curator at The Museum at FIT engage in a conversation for The Museum at FIT's 26th academic symposium “Reinvention and Restlessness: Fashion in the Nineties” on February 11 ...
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Colour Forecasting: An investigation into how its development and use impacts on accuracy [PDF]
, 2011 Colour forecasting is a sector of trend forecasting which is arguably the most important link in the product development process, yet little is known about it, the methodology behind its development or its accuracy.
King, Julie
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Indonesian Interdisciplinary Journal of Sharia EconomicsSeeing the condition of Indonesian society, which is predominantly Muslim, presents a great opportunity for the development of Muslim fashion because the interest of every Muslim in Muslim fashion products is starting to increase, and the advancement of
Eva Yulia Ningsih, Muhammad Ersya Faraby
doaj
The Influences of Fashion Trends
, 2010 Este artigo constata como as tendências são influenciadas pelos aspectos históricos, sóciopolíticos e econômicos realizando uma comparação entre estes dois períodos, a crise de 1929 aliada as duas Grandes Guerras Mundiais influenciadora do comportamento de moda no Brasil nas décadas de 30 à 50 e como a crise atual juntamente com os acontecimentos ...
openaire +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2017 An understanding of trends is a fundamental skill for anyone working in the fashion industry. In this book Gwyneth Holland and Rae Jones look at how to produce a well-researched trend, from initial inspiration to concrete idea and, eventually, real ...
Holland, G., Jones, R.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source