Results 81 to 90 of about 2,173,989 (307)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Fashion in the Nineties Symposium: "1990s Fashion Ephemera: Trends, Desire, and Exclusivity"
Graphic designer Paul Boudens and assistant professor and director of the MA in Fashion Studies at The New School Parsons Paris Dr. Marco Pecorari discuss 90s Fashion Ephemera: Trends, Desire, and Exclusivity for The Museum at FIT's 26th academic ...
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Indonesian Interdisciplinary Journal of Sharia EconomicsThis research was conducted at Universitas Pelita Bangsa Bekasi City Branch involving 86 students as respondents. The purpose of this study is to explore the influence of fashion trends, media exposure, and community on the Korean wave lifestyle, both ...
Shelly Nurhanifah, Supartono Supartono
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
BFA Fashion Show 2011: The Future of Fashion (part 1 of 5)
The best work of FIT’s graduating fashion design students is presented every spring in a professional runway show. Specializations include sportswear, special occasion, knitwear, intimate apparel, and children’s wear.The 2011 award winners: Jinsol Kim ...
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
BFA Fashion Show 2011: The Future of Fashion (part 4 of 5)
The best work of FIT’s graduating fashion design students is presented every spring in a professional runway show. Specializations include sportswear, special occasion, knitwear, intimate apparel, and children’s wear.The 2011 award winners: Jinsol Kim ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
BFA Fashion Show 2011: The Future of Fashion (part 2 of 5)
The best work of FIT’s graduating fashion design students is presented every spring in a professional runway show. Specializations include sportswear, special occasion, knitwear, intimate apparel, and children’s wear.The 2011 award winners: Jinsol Kim ...
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