Results 1 to 10 of about 1,096,011 (342)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exposing an “Intangible” Cognitive Skill Among Collegiate Football Players: II. Enhanced Response Impulse Control

Frontiers in Psychology, 2018
American football is played in a dynamic environment that places considerable demands on a player’s ability to make fast, precise reactions while controlling premature, impulsive reactions to spatial misinformation.
Theodore R. Bashore, Theodore R. Bashore, Brandon Ally, Nelleke C. van Wouwe, Joseph S. Neimat, Wery P. M. van den Wildenberg, Scott A. Wylie   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Fast impulsive reconnection and current sheet intensification due to electron pressure gradients in semi‐collisional plasmas

Geophysical Research Letters, 1996
A numerical simulation of forced reconnection and current sheet growth due to inward boundary flows in semi‐collisional plasmas is presented, and contrasted with the results of an incompressible resistive MHD simulation in the high‐Lundquist‐number regime.
Z. W. Ma, A. Bhattacharjee
openaire   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

A Novel Method for Extracting Maximum Kurtosis Component and Its Applications in Rolling Bearing Fault Diagnosis

Shock and Vibration, 2019
Rolling bearing plays an important role in the overall operation of the mechanical system; therefore, it is necessary to monitor and diagnose the bearings. Kurtosis is an important index to measure impulses.
Yonggang Xu, Zeyu Fan, Kun Zhang, Chaoyong Ma   +3 more
doaj   +1 more source

Streamer Propagation and Breakdown in a Very Small Point-Insulating Plate Gap in Mineral Oil and Ester Liquids at Positive Lightning Impulse Voltage

Energies, 2016
This article presents the results of comparative studies on streamer propagation and breakdown in a point-insulating plate electrode system in mineral oil and two ester liquids. The studies were performed for a 10-mm gap and a positive standard lightning
Pawel Rozga
doaj   +1 more source

A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse

Scientific Reports, 2021
Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction–diffusion events within nerve terminals leading to vesicular release of neurotransmitter.
Maria Reva, David A. DiGregorio, Denis S. Grebenkov   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Identification of Optimal Demodulation Frequency Band and Its Application in Fault Diagnosis of Rolling Element Bearings

机车电传动, 2019
In order to effectively extract fault impulses of rolling element bearings in the presence of low signal to noise ratio and intense non-Gaussian noise, a new method for identifying optimal demodulation frequency band was presented and applied to fault ...
Bingyan CHEN, Weihua ZHANG, Dongli SONG, Yao CHENG   +3 more
doaj