Results 51 to 60 of about 1,096,011 (342)

Bearing Fault Diagnosis Based on Energy Spectrum Statistics and Modified Mayfly Optimization Algorithm

Sensors, 2021
This study proposes a novel resonance demodulation frequency band selection method named the initial center frequency-guided filter (ICFGF) to diagnose the bearing fault. The proposed technology has a better performance on resisting the interference from
Yuhu Liu, Yi Chai, Bowen Liu, Yiming Wang   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Keto Trim Fast - Healthy Weight Loss Tips

, 2021
Keto Trim Fast Numerous people love Keto Trim Fast on the web. Directly following examining the appraisals, we observed that most individuals love Keto Trim Fast this pill.
Keto Trim Fast
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Reduced harmonic complexity of brain parenchymal cardiovascular pulse waveforms in Alzheimer’s disease

NeuroImage
Alzheimer’s disease (AD) is characterized by specific neuropathologies, and is associated with arterial wall β-amyloid accumulations, which lead to radiologically detectable amplitude increases and variable propagation speed of cardiovascular impulses in
Anssi Koivula, Vilma Perkiömäki, Mika Aho, Aleksi Rasila, Valter Poltojainen, Vesa Korhonen, Matti Järvelä, Niko Huotari, Heta Helakari, Johanna Tuunanen, Lauri Raitamaa, Tommi Väyrynen, Johanna Kruger, Vesa Kiviniemi, Janne Kananen   +14 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Numerical continuation of canard orbits in slow-fast dynamical systems

, 2009
A trajectory of a system with two clearly separated time scales generally consists of fast segments (or jumps) followed by slow segments where the trajectory follows an attracting part of a slow manifold. The switch back to fast dynamics typically occurs
Desroches, MF, Osinga, HM, Krauskopf, B
core   +1 more source

Agile acousto-optic delay line for fast impulsive stimulated Raman imaging

Optics Letters
We introduce and characterize a fast (50 kHz), long range (50 ps) and random-access optical delay line based on an acousto-optic deflector inserted in the Fourier plane of a zero-dispersion line. The advantages of this agile delay line are demonstrated in the context of impulsive stimulated Raman imaging in the low-frequency range (&
Suresh, Sisira, Martin, Ines, Metais, Samuel, Vourdaki, Chrysa, Coudreau, Sébastien, Bartels, Randy, Forget, Nicolas, Rigneault, Hervé   +7 more
openaire   +3 more sources