Results 31 to 40 of about 196,199 (218)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
InfrastructuresAviation is currently facing one of its greatest challenges: reconciling growing traffic demand with the need to drastically reduce climate-altering emissions.
Federico Del Duca +5 more
doaj +1 more source
The Fast Simulation of Scattering Characteristics from a Simplified Time Varying Sea Surface
International Journal of Antennas and Propagation, 2015 This paper aims at applying a simplified sea surface model into the physical optics (PO) method to accelerate the scattering calculation from 1D time varying sea surface. To reduce the number of the segments and make further improvement on the efficiency
Yiwen Wei, Lixin Guo, Xiao Meng
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Dynamic average modelling of renewable generation sources for real time simulation
The Journal of Engineering, 2019 The increase in microgrids and smart grid research comprising renewable generation sources with advanced grid control functionalities is driving the need for sophisticated simulation and hardware in the loop (HIL) test facilities using digital real time ...
Onyinyechi Nzimako +2 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Journal of Engineering, 2019 In a large-scale power system, electromagnetic transient simulation is facing the contradiction between simulation speed and simulation accuracy, so the electromagnetic transient models of the components in the power system have been continually being ...
Yao Shu-Jun +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
On Model Order Reduction of Interconnect Circuit Network: A Fast and Accurate Method
Mathematics, 2021 The time cost in integrated circuit simulation is an important consideration in the design. This paper investigates the model order reduction of interconnect circuit networks to facilitate numerical analysis.
Xinsheng Wang +3 more
doaj +1 more source