Results 71 to 80 of about 259,843 (288)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NMR investigation of multi-scale dynamics in ionic liquids containing Li+ and La3+: From vehicular to hopping transport mechanism

Journal of Ionic Liquids
The dynamics in mixtures of ionic liquid and monoatomic cations has been studied at different time scales ranging from the nanosecond up to the second. The mixtures were composed of cholinium bis(trifluoromethanesulfonyl)imide ([Chol][TFSI]) and LiTFSI ...
Ousmane Karé, Antonio De Souza Braga Neto, Baptiste Rigaud, Quentin Berrod, Sandrine Lyonnard, Clément Cousin, Juliette Sirieix-Plénet, Anne-Laure Rollet, Guillaume Mériguet   +8 more
doaj   +1 more source

Fast-field cycling NMR is sensitive to the method of cross-linking in BSA gels [PDF]

, 2013
This work was supported by ARUK (grant number 19689).Non peer reviewedPublisher ...
Ashcroft, G. Patrick, Broche, Lionel, Kennedy, Brett W. C., Lurie, David John   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Exploring the effect of ethanol-water structuring on the transport properties of ethanol in porous silicas

Magnetic Resonance Letters
The transport properties of liquid mixtures confined within porous media can change significantly from those observed for bulk mixtures due to changes in the liquid structuring within the pore space.
Jordan Ward-Williams, Andrew Sederman, Michael Mantle, Matthias Appel, Lynn Gladden   +4 more
doaj   +1 more source

A varactor-tuned RF coil for nuclear quadrupole double resonance with Fast Field-Cycling MRI [PDF]

, 2014
Non peer reviewedPublisher ...
Broche, Lionel, Lurie, David John, Payne, Nicholas Roy, Ross, Peter James   +3 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Parametric study of cycle modulation in laser driven ion beams and acceleration field retrieval at femtosecond timescale

Physical Review Accelerators and Beams, 2019
High-frequency modulations appearing in the kinetic energy distribution of laser-accelerated ions are proposed for retrieving the acceleration field dynamics at the femtosecond timescale.
M. Schnürer, J. Braenzel, A. Lübcke, A. A. Andreev   +3 more
doaj   +1 more source

Vertical Graphenes Grown on a Flexible Graphite Paper as an All-Carbon Current Collector towards Stable Li Deposition

Research, 2020
Lithium (Li) metal has been regarded as one of the most promising anode materials to meet the urgent requirements for the next-generation high-energy density batteries.
Zhijia Huang, Debin Kong, Yunbo Zhang, Yaqian Deng, Guangmin Zhou, Chen Zhang, Feiyu Kang, Wei Lv, Quan-Hong Yang   +8 more
doaj   +1 more source

Rapid Fast Field-Cycling Imaging using the Keyhole Technique [PDF]

, 2015
Peer reviewedPublisher ...
Lurie, David J, Ross, P James
core