Results 171 to 180 of about 382,328 (306)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A multiphysics computational model of focused ultrasound-enhanced drug delivery using temperature-sensitive liposomes. [PDF]

Biomech Model Mechanobiol
Koutsi M, Mpekris F, Stylianopoulos T.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Synaptic high-frequency jumping synchronises vision to high-speed behaviour. [PDF]

Nat Commun
Mansour N, Takalo J, Kemppainen J, Bridges AD, MaBouDi H, Asgar Bohra A, Anielska K, Vasas V, Robert T, Yi Bu B, Shukla S, Zhou Y, Kittelmann M, Ouwendijk J, Mantell J, Lawson M, de Polavieja G, Duke E, Lazar AA, Verkade P, Chittka L, Juusola M.   +21 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Machine-learning classification of motor unit types in the adult mouse. [PDF]

J Physiol
Martínez-Silva ML, Ahorklo RM, Reedich EJ, Imhoff-Manuel RD, Katenka N, Manuel M.   +5 more
europepmc   +1 more source

Inverter Fast Frequency Response is a Low-Cost Alternative to System Inertia

Electric Power Systems Research, 2023
Yamit Lavi, Jay Apt
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dynamical and Stochastic Analysis of a Piezoelectric Neuron Model for Intelligent Sensing Applications. [PDF]

Sensors (Basel)
Abdelkader A, Ehsan H, Jhangeer A.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source