Results 131 to 140 of about 2,898,059 (299)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Auvergne, Northern Territory [cartographic material] : Commonwealth topographic survey /
, 1960 Provisional ed. Topographic map of Auvergne region, Northern Territory showing classes of roads, railway and telephone lines, mines, post offices, wireless transceivers, windpumps, airports or airfields and landing grounds, horizontal control points ...
Australia. Division of National Mapping.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Multi-context seeds enable fast and high-accuracy read mapping
Genome BiologyA key step in sequence similarity search is to identify shared seeds between a query and a reference sequence. A well-known tradeoff is that longer seeds offer fast searches but reduce sensitivity in variable regions.
Ivan Tolstoganov +3 more
doaj +1 more source
Toddlers' fast-mapping from noise-vocoded speech. [PDF]
J Acoust Soc Am, 2020 Newman RS +3 more
europepmc +1 more source
Fast operator learning for mapping correlations
CoRR9 ...
Yuehaw Khoo, Yuguan Wang, Siyao Yang
openaire +3 more sources
Alroy, Northern Territory [cartographic material] : Commonwealth topographic survey /
, 1959 Provisional ed. Topographic map of Alroy Downs region, Northern Territory showing classes of roads, railway and telephone lines, mines, post offices, wireless transceivers, windpumps, airports or airfields and landing grounds, horizontal control points ...
Australia. Division of National Mapping.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mount Drummond, Northern Territory [cartographic material] : Commonwealth topographic survey /
, 1960 Provisional ed. Topographic map of Mount Drummond region, Northern Territory showing classes of roads, railway and telephone lines, mines, post offices, wireless transceivers, windpumps, airports or airfields and landing grounds, horizontal control ...
Australia. Division of National Mapping.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source