Results 171 to 180 of about 2,898,059 (299)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

News : Workshop, Mapping Architectural Criticism in China

, 2018
The workshop Mapping Architectural Criticism in China was held at the Department of Architecture, Xi'an Jiaotong-Liverpool University on April 24, 2018. You can download the full programme of the workshop here.
Mapping Architectural Criticism
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Flexible and Fast Mapping of Peptides to a Proteome with ProteoMapper. [PDF]

J Proteome Res, 2018
Mendoza L, Deutsch EW, Sun Z, Campbell DS, Shteynberg DD, Moritz RL.   +5 more
europepmc   +1 more source

Papua New Guinea, 1:50,000 topographic survey [cartographic material]

, 1973
Ed. 1-CMB. Topographic map series of Papua New Guinea showing transportation, foot tracks, water features, vegetation, plantation, buildings and villages.
Papua New Guinea. Central Mapping Bureau.
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Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Map of Norfolk Island [cartographic material] : Drawn and reproduced by the National Mapping Office, Dept. of the Interior.

, 1956
Relief shown by spot heights and contours. Contour at 100 ft.; "NMO/56/50"; Also available online http://nla.gov.au/nla.map-vn1758341.
Australia. National Mapping Office.
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Near-infrared spectroscopy-enabled electromechanical systems for fast mapping of biomechanics and subcutaneous diagnosis. [PDF]

Sci Adv
Wang Y, Henderson J, Hafiz P, Turlapati P, Ramsgard D, Lipman W, Liu Y, Zhang L, Zhang Z, Davis B, Guo Z, Wang S, Seymour L, Xie W, Bai W.   +14 more
europepmc   +1 more source

Kulgera, Northern Territory [cartographic material] : Commonwealth Topographic Survey /

, 1960
Provisional ed. Topographic map of Kulgera region, Northern Territory, showing classes of roads, railway and telephone lines, fences, state boundries, watercourses and dams, and windpumps. Relief shown by spot heights.; "Compilation: Division of National
Australia. Division of National Mapping.
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