Results 111 to 120 of about 1,296,267 (363)

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

open access: yesAdvanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi   +5 more
wiley   +1 more source

A Fast Level Set Method for Synthetic Aperture Radar Ocean Image Segmentation

open access: yesSensors, 2009
Segmentation of high noise imagery like Synthetic Aperture Radar (SAR) images is still one of the most challenging tasks in image processing. While level set, a novel approach based on the analysis of the motion of an interface, can be used to address ...
Hongga Li, Bo Huang, Xiaoxia Huang
doaj   +1 more source

A parallel Heap-Cell Method for Eikonal equations [PDF]

open access: yes, 2014
Numerous applications of Eikonal equations prompted the development of many efficient numerical algorithms. The Heap-Cell Method (HCM) is a recent serial two-scale technique that has been shown to have advantages over other serial state-of-the-art ...
Chacon, Adam, Vladimirsky, Alexander
core  

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

open access: yesAdvanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao   +16 more
wiley   +1 more source

A robust 3D crack growth method based on the eXtended Finite Element Method and the Fast Marching Method

open access: yesInternational Journal of Fracture, 2022
M. Le Cren   +3 more
semanticscholar   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

open access: yesAdvanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian   +7 more
wiley   +1 more source

The Impacts of Health and Environmental Information Nudges on Meat Choices: Where Does Goat Meat Fit?

open access: yesAgribusiness, EarlyView.
ABSTRACT Amidst a recent surge in US goat meat imports to meet growing demand, this study contributes to the meat demand literature by examining consumer preferences for goat meat, a relatively healthy and environmentally friendly alternative to other popular meats.
Binod Khanal   +2 more
wiley   +1 more source

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