Results 161 to 170 of about 1,296,267 (363)

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama   +16 more
wiley   +1 more source

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong   +9 more
wiley   +1 more source

Can social media provide early warning of retraction? Evidence from critical tweets identified by human annotation and large language models

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract Timely detection of problematic research is essential for safeguarding scientific integrity. To explore whether social media commentary can serve as an early indicator of potentially problematic articles, this study analyzed 3815 tweets referencing 604 retracted articles and 3373 tweets referencing 668 comparable non‐retracted articles. Tweets
Er‐Te Zheng   +3 more
wiley   +1 more source

Confirmation of a Non‐Transiting Planet in the Habitable Zone of the Nearby M Dwarf L 98‐59

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT Only 40 exoplanetary systems with five or more planets are currently known. These systems are crucial for our understanding of planet formation and planet‐planet interaction. The M dwarf L 98‐59 has previously been found to show evidence of five planets, three of which are transiting.
Paul I. Schwarz   +2 more
wiley   +1 more source

UAVs mission planning with flight level constraint using Fast Marching Square Method

open access: green, 2017
Verónica González   +3 more
openalex   +2 more sources

Commissioning an Inexpensive Off‐The‐Shelf Spectrograph for Radial‐Velocity Studies

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT We present a way to set up an inexpensive out of the shelf spectrograph at a local observatory. Stability and resolution of the spectrograph are high enough for radial velocity determination of binary stars or determination of stellar characteristics. Even some exoplanets might be detectable via the radial velocity method.
Lukas Stock, Andreas Schrimpf
wiley   +1 more source

Discovery and Initial Investigation of a New Low Surface Brightness Planetary Nebula Candidate at High Galactic Latitude

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT Planetary nebulae represent a late evolutionary phase of low‐ to intermediate‐mass stars. In this article, we present the serendipitous discovery of a previously unknown, faint potential Galactic planetary nebula (PN) in the constellation Camelopardalis, identified during a survey‐inspection, aiming at the detection of dwarf companions of the ...
W. E. Celnik   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy