Results 181 to 190 of about 170,377 (287)
Structural insights into urocanate reductase using room‐temperature X‐ray crystallography
Acta Crystallographica Section D, EarlyView.The active‐site dynamics of the microbial enzyme urocanate reductase were revealed by room‐temperature X‐ray crystallography.Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate‐bound versus product‐bound states.
Swati Aggarwal +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy +7 more
wiley +1 more source
Noble gases and nitrogen in material from asteroid Bennu
Meteoritics &Planetary Science, EarlyView.Abstract We report the elemental and isotopic abundances of all stable noble gases (helium, neon, argon, krypton, and xenon) in eight particles from asteroid Bennu returned by NASA's OSIRIS‐REx mission. We also report nitrogen abundances and isotopic ratios that were analyzed alongside neon and argon in four additional Bennu particles.
B. Marty +7 more
wiley +1 more source
Genomic changes and biochemical alterations of seed protein and oil content in a subset of fast neutron induced soybean mutants. [PDF]
BMC Plant Biol, 2019 Islam N +7 more
europepmc +1 more source
An unsupervised machine learning approach to iron meteorite classification
Meteoritics &Planetary Science, EarlyView.Abstract Iron meteorites are usually classified manually using bivariate elemental plots. This study extends iron meteorite classification into multi‐element space. We present a computational method for the classification of iron meteorites by applying unsupervised machine learning using density‐based cluster analysis.
Louis‐Alexandre Lobanov, Hilary Downes
wiley +1 more source
The Impact of Dose Rate on DNA Double-Strand Break Formation and Repair in Human Lymphocytes Exposed to Fast Neutron Irradiation. [PDF]
Int J Mol Sci, 2019 Nair S +9 more
europepmc +1 more source
Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight
Experimental Physiology, EarlyView.Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley +1 more source
Screening populations for copy number variation using genotyping-by-sequencing: a proof of concept using soybean fast neutron mutants. [PDF]
BMC Genomics, 2019 Lemay MA +6 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley +1 more source