Results 111 to 120 of about 7,249,875 (307)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2013 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on March 31, 2014)"Last ...
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 1979 Covers OCLC #1264104498 and OCLC #1274239742.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Experimental characterization and modelling of a cavitating centrifugal pump operating in fast start-up conditions [PDF]
, 2010 The start-up of rocket engine turbopumps is generally performed only in a few seconds. It implies that these pumps reach their nominal operating conditions after only a few rotations.
Bois, Gérard +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Fast-response humidity sensing performance based on LaFeO3 perovskite
Journal of Advanced DielectricsIn this work, LaFeO3 was synthesized via the sol–gel method and characterized to evaluate its potential for ultrafast humidity sensing applications. X-ray diffraction (XRD) confirmed the formation of a single-phase orthorhombic structure with a Pnma ...
Hoerudin Bayu Hidayah +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A high isolation transceiver-integrated RF device for multi-vehicle cooperative system
Dianzi Jishu YingyongAccording to the communication requirements of multi-vehicle cooperative system, a design method of transceiver-integrated RF device with high isolation, wide dynamic and fast response is provided.
Dai Xiaojun +3 more
doaj +1 more source