Results 121 to 130 of about 2,268,672 (291)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Transient Stability-Based Fast Power System Contingency Screening and Ranking
ElectricityToday’s power systems are operated closer to their stability limits due to the continuously growing load demands, interface to open markets, and integration of more renewable energies.
Teshome Lindi Kumissa, Fekadu Shewarega
doaj +1 more source
, 2020 Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core
, 2021 Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2020 Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Second-Order Fast Discharge Circuit for Transient Electromagnetic Transmitter
SensorsTo solve the problem of long turn-off times for transient electromagnetic (TEM) transmitters with inductive loads, a new second-order fast discharge circuit topology added into the original H-bridge structure for TEM transmitters is presented, which ...
Chao Tan +4 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source