Results 61 to 70 of about 2,268,672 (291)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Design of a thermoelectric generator with fast transient response [PDF]

Renewable Energy, 2015
Thermoelectric modules are currently used both in Peltier cooling and in Seebeck mode for electricity generation. The developments experienced in both cases depend essentially on two factors: the thermoelectric properties of the materials that form these elements (mainly semiconductors), and the external structure of the semiconductors. Figure of Merit
Fisac, Miguel, Villasevil Marco, Francisco Javier, López Martínez, Antonio Miguel   +2 more
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The Einstein Probe Transient EP240414a: Linking Fast X-Ray Transients, Gamma-Ray Bursts, and Luminous Fast Blue Optical Transients

The Astrophysical Journal Letters
Abstract Detections of fast X-ray transients (FXTs) have accrued over the last few decades. However, their origin has remained mysterious. Rapid progress is now being made thanks to timely discoveries and localizations with the Einstein Probe mission.
Joyce N. D. van Dalen, Andrew J. Levan, Peter G. Jonker, Daniele Bjørn Malesani, Luca Izzo, Nikhil Sarin, Jonathan Quirola-Vásquez, Daniel Mata Sánchez, Antonio de Ugarte Postigo, Agnes P. C. van Hoof, Manuel A. P. Torres, Steve Schulze, Stuart P. Littlefair, Ashley Chrimes, Maria E. Ravasio, Franz E. Bauer, Antonio Martin-Carrillo, Morgan Fraser, Alexander J. van der Horst, Pall Jakobsson, Paul O’Brien, Massimiliano De Pasquale, Giovanna Pugliese, Jesper Sollerman, Nial R. Tanvir, Tayyaba Zafar, Joseph P. Anderson, Lluís Galbany, Avishay Gal-Yam, Mariusz Gromadzki, Tomás E. Müller-Bravo, Fabio Ragosta, Jacco H. Terwel   +32 more
openaire   +7 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Transient response enhancement method for DC-DC converters based on adaptive duty cycle adjustment

Ain Shams Engineering Journal
This article presents an adaptive duty cycle adjustment DC-DC converter for improving load transient response. The combination of adaptive clock control and DAC output variable reference voltage allows for rapid duty cycle saturation to further increase ...
Zhongjie Guo, Ziyi Qiu, Haoliang Wang, Ningmei Yu   +3 more
doaj   +1 more source

The excess radio background and fast radio transients [PDF]

Journal of Cosmology and Astroparticle Physics, 2015
v2: updated references; 7 pages, 4 figures, 1 ...
Kehayias, John, Kephart, Thomas W., Weiler, Thomas J.   +2 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

On the origin of Supergiant Fast X-ray Transients [PDF]

Proceedings of the International Astronomical Union, 2018
Abstract. A fraction of high-mass X-ray binaries are supergiant fast X-ray transients. These systems have on average low X-ray luminosities, but display short flares during which their X-ray luminosity rises by a few orders of magnitude. The leading model for the physics governing this X-ray behaviour suggests that the winds of the donor OB supergiants
Hubrig, Swetlana, Sidoli, Lara, Postnov, Konstantin A., Schöller, Markus, Kholtygin, Alexander F., Jarvinen, Silva P.   +5 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source