Results 171 to 180 of about 864,998 (268)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

The Evolving Biliary Multi-Omics Framework in Gallbladder Cancer: A Reply to Critiques on Confounders, Viability, and Host Defenses. [PDF]

J Gastroenterol Hepatol
Das D, Dixit R, Pandey M.
europepmc   +1 more source

CLSI Addresses Susceptibility Testing of Fastidious Bacteria in New Guideline [PDF]

Laboratory Medicine, 2011
openaire   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Extragenital <i>Mycoplasma hominis</i> infection following obinutuzumab therapy in a patient with chronic lymphocytic leukemia. [PDF]

IDCases
Benandi K, Blanton LS.
europepmc   +1 more source

Antibiotic Susceptibility of Fastidious and Non-fastidious Bacteria from African Swine Fever Pigs to Standard Antibiotics and ‘Luwine’

Current Research in Bacteriology, 2018
Frederick Adzitey, Godfred Aweligiya, Rejoice Ekli   +2 more
openaire   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Probable Bartonella clarridgeiae Prosthetic Valve Endocarditis and Aortic Root Abscess, Australia, 2020. [PDF]

Emerg Infect Dis
Cribb M, Coghill S.
europepmc   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

<i>Ureaplasma parvum</i> septic arthritis in LRBA deficiency: An infectious mimic of autoimmune arthritis. [PDF]

J Hum Immun
Timmermans K, De Vriendt C, Vandendriessche S, Pottie L, Roels L, Tavernier SJ, Haerynck F, Callens S, Naesens L.   +8 more
europepmc   +1 more source