Results 141 to 150 of about 330,432 (260)

Gender-specific age inflection points for hypertension, elevated fasting blood glucose, and dyslipidemia in a Northern Chinese cohort: a comorbidity-based analysis. [PDF]

BMC Public Health
Xiaonan L, Zhiyong H, Meihan C, Dan H.
europepmc   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Early-pregnancy fasting blood glucose and subsequent GDM define four distinct risk groups for adverse pregnancy outcomes: a cohort study of 15,245 women. [PDF]

Front Endocrinol (Lausanne)
Li J, Zhang J, Zhang C, Liang X, Lu Y, Wu H.   +5 more
europepmc   +1 more source

Fasting blood glucose concentrations and treatment of maturity-onset diabetes. [PDF]

BMJ, 1980
Howedavies, S, Muir, A, Holman, R, Turner, R   +3 more
openaire   +3 more sources

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Fasting blood glucose to HDL-C ratio as a potential biomarker for prostate cancer risk classification. [PDF]

BMC Urol
Özkan S, Börekoğlu A.
europepmc   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Association Between Fasting Blood Glucose and Myocardial Infarction Risk: Findings From the 2015-2018 NHANES Database and Mendelian Randomization Studies. [PDF]

Cardiol Res Pract
Peng B, Liang J, Yuan L, Lin D, Fan X.
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Glycemic trajectories of fasting blood glucose on the pathological responses in breast cancer women with and without concomitant diabetes. [PDF]

PLoS One
Javed S, Javed U, Mohamed Noor DA, Hanafiah NHM, Mustafa T, Rehman AU, Noor Harun S.   +6 more
europepmc   +1 more source