Results 201 to 210 of about 330,432 (260)

Fasting Blood Glucose on Prognosis After Acute Large Vessel Occlusion Reperfusion- A Multi-Center Study Based on Propensity Score Matching. [PDF]

Vasc Health Risk Manag
Luo B, Xiang Y, Pan Y, Meng F, Zhang J, Liu Z, Lin P, Zhang L, Wang Y, Ren H, Ma L, Huang Y.   +11 more
europepmc   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Correlation of cumulative fasting blood glucose exposure with gastrointestinal cancers: A prospective cohort study. [PDF]

Medicine (Baltimore)
Liu K, Wang W, Liu Y, Li J, Ma C, Tian Y, Dong Z, Zhu L, Wei W, Ren M, Wu S, Liu S.   +11 more
europepmc   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies. [PDF]

Mol Metab
Roell W, Alsina-Fernandez J, Qu H, Coskun T, Benson C, Haupt A, Kelly RP, O'Farrell L, Sloop KW, Steele JP, Ficorilli J, Regmi A, Rettiganti M, Urva S, Mather KJ, Pratt E.   +15 more
europepmc   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Association between fasting blood glucose level and difficulty with chewing: the Aichi Workers' Cohort Study. [PDF]

Environ Health Prev Med
Hamrah MH, Song Z, Hong Y, Akter T, Nuamah HG, Gondo N, Matsunaga M, Ota A, Takada M, Otsuka R, Tamakoshi K, Yatsuya H.   +11 more
europepmc   +1 more source

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

Relationship Between Fasting Blood Glucose to High-Density Lipoprotein Cholesterol Ratio (GHR) and Coronary Artery Vascular Lesions: A Retrospective Cross-Sectional Study. [PDF]

Int J Gen Med
Yan HB, Liu ZX, Yang YJ, Liu C, Yang ZC, Wang Y, Xu X, Liu WT, Wang XH, Zhang YN, He H.   +10 more
europepmc   +1 more source

Moderate altitude exposure impacts extensive host-microbiota multi-kingdom connectivity with serum metabolome and fasting blood glucose. [PDF]

Virulence
Huang X, Gao X, Fan Y, Wang D, Chen X, Qi X, Yang Z, Wang YE, Meng J, Zou G, Liu Z, Li X.   +11 more
europepmc   +1 more source