Results 151 to 160 of about 533,332 (304)
Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang +19 morewiley +1 more sourceA missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
, 2020 A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan ...F Unasa-Apelu (13502533), Rachel Duckham (13067928), DE Weeks (14594813), NL Hawley (9665240), EE Kershaw (14594807), KJ Arslanian (14865142), AI Wetzel (9665237), A Pomer (13502539), T Atanoa (13304508), T Naseri (9665228), ST McGarvey (9198116), JA Strayer (14865154), UT Fidow (14865151) +12 morecore Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness
Advanced Science, EarlyView.ABSTRACT
Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao +7 morewiley +1 more sourceAssociation between fat mass index and fat-free mass index values and cardiovascular risk in adolescents
, 2016 ObjectiveTo describe the association between fat mass index and fat-free mass index values and factors associated with cardiovascular risk in adolescents in the city of Juiz de Fora, Minas Gerais.MethodsCross-sectional study was with 403 adolescents aged Oliveira,Patrícia Morais de, Michele Pereira Netto, Patrícia Morais de Oliveira, Fabiana Almeida da Silva, Mendes,Larissa Loures, Mendes, Larissa Loures, da Silva, Fabiana Almeida, de Oliveira, Patrícia Morais, Fabiana Almeida da Silva (5084300), Netto, Michele Pereira, Ana Paula Carlos Cândido, Ana Paula Carlos Cândido Mendes, Larissa Loures Mendes (2511811), Cândido,Ana Paula Carlos, Cândido, Ana Paula Carlos, Patrícia Morais de Oliveira (5084294), Renata Maria Souza Oliveira (5084297), Renata Maria Souza Oliveira e Silva, Oliveira,Renata Maria Souza, Oliveira, Renata Maria Souza, Ana Paula Carlos Cândido (4770345), Silva,Fabiana Almeida da, Pereira Netto,Michele, Renata Maria Souza Oliveira, Patrícia Morais de Oliveira, Michele Pereira Netto (5084303), Larissa Loures Mendes +26 morecore +1 more sourcePET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao +14 morewiley +1 more sourceEnhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao +8 morewiley +1 more sourceZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction
Advanced Science, EarlyView.ABSTRACT
Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin +14 morewiley +1 more sourceCanagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin +32 morewiley +1 more sourceCorrigendum: Very low calorie ketogenic diet combined with physical interval training for preserving muscle mass during weight loss in sarcopenic obesity: A pilot study
Frontiers in Nutrition, 2022 Elisabetta Camajani, Elisabetta Camajani, Alessandra Feraco, Alessandra Feraco, Stefania Proietti, Sabrina Basciani, Luigi Barrea, Luigi Barrea, Andrea Armani, Andrea Armani, Mauro Lombardo, Lucio Gnessi, Massimiliano Caprio, Massimiliano Caprio +13 moredoaj +1 more source
