Results 71 to 80 of about 7,077,537 (255)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Average estimated fat mass and fat-free mass at birth, fat mass and fat-free mass velocities from birth to 6 months of age estimated with linear-spline mixed-effects modelling, and estimated fat mass and fat-free mass at 6 months in Ethiopian children¹.

, 2019
Average estimated fat mass and fat-free mass at birth, fat mass and fat-free mass velocities from birth to 6 months of age estimated with linear-spline mixed-effects modelling, and estimated fat mass and fat-free mass at 6 months in Ethiopian children1.
Alemseged Abdissa (360998), Henrik Friis (345267), Marit E. Jørgensen (6667144), Gregers S. Andersen (6505526), Dorte Vistisen (162807), Kim F. Michaelsen (6992624), Jonathan C. K. Wells (7108898), Bitiya Admassu (7288367), Rasmus Wibaek (5864339), Tsinuel Girma (6078650), Mubarek Abera (7288370), Pernille Kæstel (2832632)   +11 more
core   +1 more source

Differences in body composition between infants of South Asian and European ancestry: the London Mother and Baby Study. [PDF]

, 2012
BACKGROUND: South Asian children and adults have a more adipose body composition compared with those of European ancestry. This is thought to be related to their increased risk of metabolic disorders. However, little is known about how early in life such
Stanfield, KM, Chris Frost, Frost, C, Frost, Chris, Stanfield, Kristina M, Fewtrell, MS, Kristina M Stanfield, David A Leon, Leon, DA, Leon, David A, Wells, Jonathan C, Fewtrell, Mary S, Mary S Fewtrell, Wells, JC, Jonathan C Wells   +14 more
core   +1 more source

Muscle strength and body composition in severe obesity

Clinics
OBJECTIVE: The aim of our study was to evaluate associations between maximum voluntary contraction torques of the lower limbs and body composition for subjects with severe obesity.
Alexandre Vieira Gadducci, Roberto de Cleva, Gabriela Correia de Faria Santarém, Paulo Roberto Santos Silva, Julia Maria D’Andréa Greve, Marco Aurélio Santo   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Smoking significantly increases basal metabolic rate in patients with rheumatoid arthritis. [PDF]

, 2008
OBJECTIVE: Basal metabolic rate (BMR) is the most important indicator of human metabolism and its abnormalities have been linked to undesirable health outcomes.
Metsios, Giorgos S., Stavropoulos-Kalinoglou, Antonios, Koutedakis, Yiannis, Douglas, Karen M. J., Nevill, Alan M., Kitas, George D.   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source