Results 141 to 150 of about 316,025 (294)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Role of ultra-processed food in fat mass index between 6 and 11 years of age: a cohort study. [PDF]

Int J Epidemiol, 2021
Costa CDS, Assunção MCF, Loret de Mola C, Cardoso JS, Matijasevich A, Barros AJD, Santos IS.   +6 more
europepmc   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Bioelectrical impedance analysis for measuring body composition and predicting low muscle mass in apparently healthy pediatric outpatients: a retrospective observational study

BMC Pediatrics
Background The bioelectrical impedance analysis–derived phase angle is a proposed indicator of sarcopenia in adults. This study assessed the body composition of pediatric outpatients without underlying medical conditions to evaluate the predictive value ...
Qiongyao Hu, Qi Long, Wenqiao Wang, Ming Ma   +3 more
doaj   +1 more source

Replacing body mass index with relative fat mass to accurately estimate adiposity

Nature Reviews Endocrinology
Body mass index (BMI), as its name indicates, is a marker of total body mass and not a specific marker of adipose tissue mass. Here, we position relative fat mass (RFM) as an ideal alternative to BMI by highlighting the superior performance of RFM in assessing cardiometabolic risk.
Navin Suthahar, Richard N. Bergman, Rudolf A. de Boer   +2 more
openaire   +2 more sources

Increased Anti‐Psoriatic Effect of Anti‐Inflammatory Dendrimers Using Fluid Catanionic Vesicle‐Based Topical Formulations

Advanced Healthcare Materials, EarlyView.
Next‐Generation Psoriasis Therapy – With advanced dendrimer‐based formulations, this study paves the way for highly effective, skin‐permeable treatments. Encapsulated in fluid catanionic vesicles, IMD‐006 and its analogues show promising anti‐psoriatic effects offering a targeted, non‐invasive approach to managing chronic skin inflammation.
Ranime Jebbawi, Abdelouahd Oukhrib, Emily Clement, Hélène Labie, Stéphanie Cassel, Séverine Fruchon, Anne‐Marie Caminade, Michel Simon, Rémy Poupot, Cédric‐Olivier Turrin, Muriel Blanzat   +10 more
wiley   +1 more source

Association of Rotating Night Shift Work with Body Fat Percentage and Fat Mass Index among Female Steelworkers in North China. [PDF]

Int J Environ Res Public Health, 2021
Zhang S, Wang H, Wang Y, Yu M, Yuan J.
europepmc   +1 more source

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes

, 2021
Marília O. Scliar, Hanaísa P. Sant Anna, Meddly L. Santolalla, Thiago Peixoto Leal, Nathalia Matta Araujo, Isabela Alvim, Víctor Borda, Wagner C. S. Magalhães, Mateus H. Gouveia, R.O.C. Lyra, Moara Machado, Lucas A. Michelin, Maíra R. Rodrigues, Gilderlânio Santana de Araújo, Fernanda S. G. Kehdy, Camila Zolini, Sérgio Viana Peixoto, Marcelo R. Luizon, Francisco Pereira Lobo, Michel Satya Naslavsky, Guilherme Lopes Yamamoto, Yeda A. O. Duarte, Matthew E.B. Hansen, Shane A. Norris, Robert H. Gilman, Heinner Guio, Ann W. Hsing, Sam M. Mbulaiteye, James E. Mensah, Julie Dutil, Meredith Yeager, Edward D. Yeboah, Sarah A. Tishkoff, Ananyo Choudhury, Michèle Ramsay, Maria Rita Passos‐Bueno, Mayana Zatz, Timothy D. O ́Connor, Alexandre C. Pereira, Maurício L. Barreto, Maria Fernanda Lima‐Costa, Bernardo Lessa Horta, Eduardo Tarazona‐Santos   +42 more
openalex   +2 more sources