Results 81 to 90 of about 1,171,043 (349)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
A. Abdelrahman, A. F. Pfeiffer, AR Josse, AW Barclay, B. Thorens, C Yamada, C Zhang, Coon PJ, Rogus EM, Drinkwater D, Muller DC, Goldberg AP, DB Pawlak, DB Pawlak, DS Ludwig, DW Foster, EM Schothorst van, EO Diaz, F Isken, F Isken, F Preitner, F. Isken, J Brand-Miller, J Salmeron, J Salmeron, J Stevens, JA Marshall, JJ Holst, JJ Meier, K Miyawaki, KA Meyer, KB Scribner, KB Scribner, KH Ding, M Kabir, M Lerer-Metzger, M. H. Tschöp, M. Möhlig, M. O. Weickert, MB Schulze, MK Hellerstein, MO Weickert, R. Nogueiras, RM Dam van, S Liu, S. Klaus, SE Byrnes, SJ Gatenby, WM Kohrt, X Pi-Sunyer   +45 more
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Cross-sectional and prospective impact of reallocating sedentary time to physical activity on children's body composition. [PDF]

, 2016
BACKGROUND: The amount of time children spend in sedentary behaviours may have adverse health effects. OBJECTIVE: To examine the substitution effects of displacing a fixed duration of sedentary time with physical activity (PA) on children's body ...
Ekelund, Ulf, Marques, Adilson, Minderico, Cláudia, Sardinha, Luís B   +3 more
core   +2 more sources

The novel expression method of pediatric body composition : fat mass index and fat-free mass index

Korean Journal of Pediatrics, 2007
Purpose : This study was conducted to assess the usefulness of fat-free mass index (FFMI) and fat mass index (FMI) as novel expression methods of body composition in children. Methods : A total of 466 Second grade students-248 boys and 218 girls- from all elementary schools the Gwacheon City underwent anthropometric measures including bioelectrical ...
Kyung A Kim, Myeong Ho Jung, Young Gyu Cho, Jae Heon Kang, Hye Ryoung Song, Ji Hyun Song   +5 more
openaire   +2 more sources

Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index.

European Heart Journal, 2019
AIMS Central adiposity is associated with increased cardiovascular disease (CVD) risk, even among people with normal body mass index (BMI). We tested the hypothesis that regional body fat deposits (trunk or leg fat) are associated with altered risk of ...
Guo-Chong Chen, R. Arthur, N. Iyengar, Victor Kamensky, X. Xue, S. Wassertheil-Smoller, M. Allison, A. Shadyab, R. Wild, Yangbo Sun, Hailey R Banack, J. Chai, J. Wactawski‐Wende, J. Manson, M. Stefanick, A. Dannenberg, T. Rohan, Q. Qi   +17 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Association of Pro-Healthy Diet Index and Non-Healthy Diet Index with Body Composition: Baseline Results from Cohort Study [PDF]

International Journal of Nutrition Sciences
Background: Various dietary patterns have different effects on the body composition of adults. This study investigated the association of pro-healthy diet index (PHDI) and non-healthy diet index (NHDI) with body composition in employees of Shiraz ...
Nafise Davoudzadeh, Seyed Jalil Masoumi, Mehran Nouri, Zahra Sohrabi   +3 more
doaj   +1 more source

Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study

JAMA Oncology, 2019
Importance Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)–positive subtype in postmenopausal women.
N. Iyengar, R. Arthur, J. Manson, R. Chlebowski, Candyce H. Kroenke, L. Peterson, T. Cheng, E. Feliciano, D. Lane, Juhua Luo, R. Nassir, K. Pan, S. Wassertheil-Smoller, Victor Kamensky, T. Rohan, A. Dannenberg   +15 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source