Results 71 to 80 of about 344,930 (285)

Role of a Critical Visceral Adipose Tissue Threshold (CVATT) in Metabolic Syndrome: Implications for Controlling Dietary Carbohydrates: A Review [PDF]

, 2004
There are likely many scenarios and pathways that can lead to metabolic syndrome. This paper reviews mechanisms by which the accumulation of visceral adipose tissue (VAT) may contribute to the metabolic syndrome, and explores the paradigm of a critical ...
Freedland, Eric S.
core   +5 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Effects of 8-weeks of daily time restricted feeding and aerobic exercise on fat oxidation – A randomized controlled trial

Current Issues in Sport Science
Introduction & Purpose Substrate metabolism, especially lipid metabolism and thus fat oxidation, is of special interest to reduce the risk of metabolic diseases (diabetes, high cholesterol or triglycerides, etc), and improve athletic performance ...
Florian Hofstaetter, Linda Rausch, Martin Niedermeier, Martin Kopp, Justin Lawley   +4 more
doaj   +1 more source

Optimizing Maximal Fat Oxidation Assessment by a Treadmill-Based Graded Exercise Protocol: When Should the Test End?

Frontiers in Physiology, 2019
Maximal fat oxidation during exercise (MFO) and the exercise intensity eliciting MFO (Fatmax) are considered important factors related to metabolic health and performance. Numerous MFO and Fatmax data collection and analysis approaches have been applied,
Francisco J. Amaro-Gahete, Francisco J. Amaro-Gahete, Guillermo Sanchez-Delgado, Jørn W. Helge, Jonatan R. Ruiz   +4 more
doaj   +1 more source

Maximum Aerobic Function: Clinical Relevance, Physiological Underpinnings, and Practical Application

Frontiers in Physiology, 2020
The earliest humans relied on large quantities of metabolic energy from the oxidation of fatty acids to develop larger brains and bodies, prevent and reduce disease risk, extend longevity, in addition to other benefits.
Philip Maffetone, Philip Maffetone, Paul B. Laursen   +2 more
doaj   +1 more source

Meat and cancer: haemoglobin and haemin in a low calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats [PDF]

, 2003
High intake of red meat, but not of white meat, is associated with an increased risk of colon cancer. However, red meat does not promote cancer in rodents.
Corpet, Denis E., Petit, Claude, Pierre, Fabrice, Taché, Sylviane, Van der Meer, Roleof   +4 more
core   +5 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Contextualising Maximal Fat Oxidation During Exercise: Determinants and Normative Values

Frontiers in Physiology, 2018
Using a short-duration step protocol and continuous indirect calorimetry, whole-body rates of fat and carbohydrate oxidation can be estimated across a range of exercise workloads, along with the individual maximal rate of fat oxidation (MFO) and the ...
Ed Maunder, Daniel J. Plews, Andrew E. Kilding   +2 more
doaj   +1 more source

A comparison of substrate oxidation during prolonged exercise in men at terrestrial altitude and normobaric normoxia following the coingestion of 13C glucose and 13C fructose [PDF]

, 2017
This study compared the effects of co-ingesting glucose and fructose on exogenous and endogenous substrate oxidation during prolonged exercise at altitude and sea level, in men.
Adopo, Aragones, Batterham, Beidleman, Borg, Bouissou, Brooks, Brooks, Brooks, Brooks, Conkin, Costill, Craig, Craig, Dill, Fenn, Ferraris, Friedmann, Fulco, Gilde, Hawley, Hinkle, Huang, Jentjens, Jentjens, Jones, Katayama, Kuipers, Lundby, Morrison, Morrison, Mosora, Ni, Pallikarakis, Paul, Peronnet, Peronnet, Peronnet, Peronnet, Peters, Roberts, Roberts, Ruderman, Shi, Smith, Spriet, Trimmer, Wagenmakers, Wasserman, Wright, Young   +50 more
core   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source