Results 31 to 40 of about 62,626 (241)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

open access: yesArthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead   +4 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

open access: yesArthritis Care &Research, Accepted Article.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among long‐term HCQ users with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain OCT (SD‐OCT) for screening. Methods A systematic search of PubMed, Scopus,
Narsis Daftarian   +4 more
wiley   +1 more source

Transient facial paresis as a complication of buccal fat removal

open access: yesJPRAS Open
Aim: This case highlights the rarely reported complication of facial paresis following buccal fat pad removal and its management. Background: The buccal fat pad is a vital structure in facial aesthetics.
Alexa Franco   +3 more
doaj   +1 more source

An unusual presentation of Hoffa’s disease in an elderly patient with no trauma history: a case report

open access: yesActa Orthopaedica et Traumatologica Turcica, 2020
Hoffa’s fat pad disease usually occurs in young active patients participating in activities involving repetitive microtrauma to the knee joint. No specific radiographic findings associated with the disease has yet been defined.
Jong-Hoon Park   +3 more
doaj   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

open access: yesAdvanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava   +7 more
wiley   +1 more source

Identification of novel adipokines in the joint. Differential expression in healthy and osteoarthritis tissues. [PDF]

open access: yesPLoS ONE, 2015
OBJECTIVES:Emerging data suggest that several metabolic factors, released mainly by white adipose tissue (WAT) and joint tissues, and collectively named adipokines, might have a role in the pathophysiology of OA.
Javier Conde   +9 more
doaj   +1 more source

Self‐Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants

open access: yesAdvanced Functional Materials, EarlyView.
ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian   +5 more
wiley   +1 more source

Flexibility of infrapatellar fat pad affecting anterior knee pain 6 months after anterior cruciate ligament reconstruction with hamstring autograft

open access: yesScientific Reports, 2020
This study aimed to identify factors affecting anterior knee pain (AKP) after anterior cruciate ligament reconstruction (ACLR) with hamstring tendon autograft using ultrasonography.
Takashi Kitagawa   +7 more
doaj   +1 more source

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