Results 101 to 110 of about 113,942 (235)

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Retrospective analysis of pembrolizumab-related adverse reactions and death outcomes based on the FAERS database

BMC Cancer
Objective This study aimed to analyze the characteristics of adverse reactions in cancer patients treated with Pembrolizumab based on the U.S.
Huilin Xu, Ying Huang, Nan Zhao, Han Hu, Dedong Cao   +4 more
doaj   +1 more source

Does Climate Risk Affect Employment Decisions? International Evidence

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the effect of climate risk on corporate employment decisions. Using a large sample from 41 countries, we find a positive association between climate risk and underinvestment in labor, notably manifesting as excessive employee layoffs.
Claude Francoeur, Faten Lakhal, Hamza Nizar, Zvi Singer   +3 more
wiley   +1 more source

Preoperative hemoglobin predicts clinical outcomes after percutaneous coronary intervention

BMC Cardiovascular Disorders
Background Concurrent anemia is associated with an increased risk of major adverse cardiac events (MACE) in patients with myocardial infarction. The study aimed to assess the value of anemia and preoperative hemoglobin levels in predicting clinical ...
Hailang Liu, Chunyang Yu, Tingting Hu, Zhongcheng Wei, Jin Geng, Xiwen Zhang   +5 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

A pharmacovigilance data–driven approach to reveal high fatal adverse events following checkpoint immunotherapy

Proceedings of the National Academy of Sciences
Immune checkpoint inhibitors (ICIs) have significantly improved the outcome of cancer treatment, but they also expose most patients to a variety of treatment-related adverse events (AEs). This study introduces a modified pharmacovigilance approach to identify “ICI-related high-mortality AEs”, a subset of treatment-related complications that are ...
Zhen Sun, Xuan Deng, Jianglong Guo, Mengsi Liu, Siying Wang, Jian Wang, Jiaojiao Zheng, Kongyan Niu, Weiming Shen, Zhen Ye, Chongming Zheng, Hongye Wang, Fan Yang, Zhouzhou Bao, Kui Ming Chan, Gang Chen, Ming Guan, Haojie Jin   +17 more
openaire   +2 more sources

Long‐Term Trends in Cardiac Erosion After Transcatheter Closure of Atrial Septal Defects With the Amplatzer Septal Occluder

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Trends in cardiac erosion after closure of secundum atrial septal defects (ASD) with the Amplatzer Septal Occluder (ASO) have not been assessed since updates were made to the Instructions for Use in 2012 and 2018. This study evaluates the incidence and demographics of ASO erosion over time since its introduction in 1996.
Daniel S. Levi, Doff B. McElhinney
wiley   +1 more source

The High‐Sensitivity C‐Reactive Protein−Albumin−Lymphocyte Index Is a Prognostic Marker for All‐Cause and Cardiovascular Mortality in Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Inflammation and immune dysfunction may worsen the prognosis of patients with ST‐segment elevation myocardial infarction (STEMI). Aims This study aimed to assess whether the high‐sensitivity C‐reactive protein–albumin–lymphocyte index (hsCALLYI) could be used to predict the prognosis of STEMI patients who received emergency ...
Xinuo Ma, Wei Zhang, Ningli Zhang, Qinghua Zhong, Tao Shi, Sirui Yang, Fazhi Yang, Yujuan Peng, Lixing Chen   +8 more
wiley   +1 more source

Treatment‐Related Adverse Events of Antibody‐Drug Conjugate Monotherapy in Non‐Small Cell Lung Cancer: A Systematic Review and Meta‐Analysis

Thoracic Cancer
Background Antibody‐drug conjugates (ADCs) have demonstrated promising efficacy in several prospective clinical studies, offering new possibilities for the treatment of non‐small cell lung cancer (NSCLC).
Yuwei Li, Linjing Zhou, Sini Li, Shichao Zhou, Yunfei Chen, Yunfeng Tong, Jing Sun, Le Wang, Yun Fan   +8 more
doaj   +1 more source

Drug‐Coated Balloon‐Based Strategy for De Novo Coronary Artery Disease Across Complex and High‐Risk Indicated Percutaneous Coronary Intervention Risk Categories: A Multicenter Registry Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Evidence regarding the risk‐stratified effectiveness of drug‐coated balloon (DCB)‐based PCI for de novo coronary artery disease (CAD) remains limited, particularly in patients undergoing complex and high‐risk indicated percutaneous coronary intervention (CHIP PCI).
Dong Oh Kang, Sunwon Kim, Ae‐Young Her, Eun‐Seok Shin   +3 more
wiley   +1 more source