Results 151 to 160 of about 222,124 (263)

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Selective Sequential Depolymerization of Mixed Plastics Mediated by Photothermal Conversion

Angewandte Chemie, EarlyView.
This work provides a selective sequential depolymerization strategy for mixed plastic waste. The method enables depolymerization of poly(L‐lactide), polystyrene, and poly(ethylene terephthalate), including their post‐consumer plastics. Without presorting, monomer separation is achieved by leveraging the distinct chemical reactivities of each polymer in
Yoon‐Jung Jang, Angela Milo, Deepika Shingwekar, Hanning Jiang, Erin E. Stache   +4 more
wiley   +2 more sources

Histopathological Changes as a Predictor of Fatal Outcome in Patients With Drug-Induced Liver Injury. [PDF]

Liver Int
Weber S, Erhardt F, Neumann J, Allgeier J, Saka D, Donga N, Mircheva I, Balakumar R, Lange CM, Gerbes AL.   +9 more
europepmc   +1 more source

Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in CHIMES: A Single‐Arm Clinical Trial

Annals of Neurology, EarlyView.
Objective To evaluate the effectiveness and safety of ocrelizumab in self‐identified black and Hispanic people with relapsing multiple sclerosis. Methods The Characterization of Ocrelizumab in Minorities with Multiple Sclerosis (CHIMES) trial, a prospective, open‐label, single‐arm, phase 4 study, intentionally recruited underrepresented populations in ...
Lilyana Amezcua, Anthony T. Reder, Evanthia Bernitsas, Nancy L. Monson, Timothy Vartanian, Gregory F. Wu, Mansoor Saleh, Annette Okai, Ahmed Z. Obeidat, Dilraj Sokhi, Rikisha Parekh, Jinglan Pei, Christopher Harp, David Clayton, Ibraheem Abioye, Mitzi J. Williams, for the CHIMES Study Group   +16 more
wiley   +1 more source

Metastatic Paraganglioma With a Fatal Outcome Following Liver Biopsy: A Case Report. [PDF]

Cureus
Hipólito-Reis I, Jorge N, Cruz F, Nogueira S, Paiva JA.   +4 more
europepmc   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

A rare but fatal outcome is hepatocellular carcinoma (HCC) progressing to the right atrial tumor thrombus and inferior vena cava. [PDF]

Radiol Case Rep
Hoai LT, Ngoc ADT, Hoang NV, Van Phuong NN, Van Tho V, Luan VD.   +5 more
europepmc   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Pembrolizumab Failure in an Aggressive, Platinum-Resistant Primary Mediastinal Yolk Sac Tumor With Rapid Metastatic Dissemination, Spinal Cord Compression, and a Fatal Outcome. [PDF]

Cureus
Riyadh S, Cline G.
europepmc   +1 more source

Early-Onset Monogenic Obesity due to Leptin Receptor Deficiency: Fatal Outcome in Childhood in the Era of Precision Therapy.

Horm Res Paediatr
Tercan U, Kandemir T, Kardelen AD, Bas Ikizoglu N, Poyrazoglu S, Darendeliler F, Bas F, Yildiz M.   +7 more
europepmc   +1 more source