Results 41 to 50 of about 221,665 (266)

Factores asociados al trauma fatal en motociclistas en Medellín, 2005-2008

Biomédica: revista del Instituto Nacional de Salud, 2012
Introducción. En medio de un cambio en la movilidad vial, en el que la motocicleta se ha generalizado como herramienta de transporte y de trabajo, se da el trauma en motociclistas que genera consecuencias desfavorables para la salud pública, por lo que ...
Doralba Aristizábal, Germán González, John Fredy Suárez, Piedad Roldán   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Analysis of Cases of Mild Head Trauma Resulting in Fatal Outcome from the Doctor Helicopter Registry Data

Journal of Emergencies, Trauma and Shock
Introduction: In cases of mild head trauma, there have been no comprehensive studies on cases that resulted in death. This study aims to conduct a factor analysis of mild head trauma cases resulting in death. Patients with Glasgow Coma Scale (GCS) scores
Youichi Yanagawa, Hiroaki Taniguchi, Chihiro Maekawa, Noriko Tanaka, Kenji Kawai, Michika Hamada, Soichiro Ota, Hiroki Nagasawa   +7 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Emamectin·chlorfenapyr-induced fatal leukoencephalomyelopathy with delayed hyperthermia: insecticide endanger public safety

Frontiers in Neurology
BackgroundEmamectin·chlorfenapyr is a compound comprising chlorfenapyr and emamectin benzoate that is widely used in agriculture. Chlorfenapyr toxicity has been verified in animals; however, its true mechanism and progression in humans remain to be ...
Xun Li, Yun Yang, Yajing Zhang, Xuebin Zhang, Na Zhao, Wei Yue, Wei Yue   +6 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Septic Polyarthritis with Fatal Outcome in Rheumatoid Arthritis: A Consequence of Corticosteroid Injection and Unsupervised Immunosuppressive Polypharmac [PDF]

Batna Journal of Medical Sciences
Septic polyarthritis is a rare but severe form of septic arthritis associated with high morbidity and mortality, particularly in patients with rheumatoid arthritis receiving immunosuppressive therapy.
Assia HADDOUCHE, Safa AMMAR BOUDJELAL, Hind ARZOUR BELAMINE, Fella HANNI   +3 more
doaj   +1 more source

Melioid meningitis: First reported case of Burkholderia pseudomallei meningitis In Colombia

Clinical Infection in Practice, 2023
Human melioidosis is a serious infectious disease commonly known by being endemic in southeast Asia and northern Australia. It is caused by Burkholderia pseudomallei a non-spore forming gram negative bacillus.
Santiago Sanchez-Pardo, Sebastián Mackenzie-Martinez, Samuel Martinez-Vernaza, Gloria Cecilia Cortés Fraile, Sandra Milena Gualtero Trujillo   +4 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source