Results 131 to 140 of about 2,421,411 (338)
Advanced Science, EarlyView.This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou +17 more
wiley +1 more source
Yi, Observational Documentary Aesthetics, and the Identity Politics of Transcultural Migrancy [PDF]
, 2017 There is a moment in Edward Yang’s acclaimed film Yi Yi (2000) in which a young boy in a conversation with his father observes that he cannot see what his father sees and that his father cannot see what he sees, prompting two questions: “How can I know ...
Xu, Jiacheng, 4159187
core +1 more source
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
The Rise of Single Fathers: A Ninefold Increase Since 1960 [PDF]
, 2013 A record 8% of households with minor children in the United States are headed by a single father, up from just over 1% in 1960, according to a Pew Research Center analysis of Decennial Census and American Community Survey data.The number of single father
Gretchen Livingston
core
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced Science, EarlyView.ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
, 2017 Materials promoting a CineAfriq@BU film screening of "The Father", followed by a discussion with the director, Ermias Woldeamlak, via video ...
Sexton, Samantha
core
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Relations in the Trinitarian Reality: Two approaches [PDF]
, 2014 The Greek model of the Trinity, based on the Theological Orations of Gregory of Nazianzus, treats the Trinitarian relations as connections between the Father and the two other persons: the Son and the Holy Spirit.
Butakov, Pavel
core +1 more source