Results 51 to 60 of about 14,270 (287)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

The Tato.Net Initiative – A Program Developed by the Cyryl and Metody Foundation in Support of Contemporary Fatherhood

Paedagogia Christiana
This study aims to present the operation of the Tato.Net Initiative [Dad.Net] implemented by the Cyryl and Metody Foundation (hereafter referred to as the Foundation).
Patrycja Kaszubska-Dziergas
doaj   +1 more source

Fatherhood as transition: The contemporary relevance of transition theory [PDF]

, 2002
This chapter explores the contemporary utility of ritual transition theory (Van Gennep [1909], 1960). Drawing on qualitative data generated during a longitudinal ethnographic study of men’s transition to fatherhood, the paper describes how the three ...
Draper, Jan, Draper, Janet
core  

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

PATERNIDADE: UM ESTUDO SOBRE PESQUISAS DESENVOLVIDAS NO CONTEXTO BRASILEIRO.

Colloquium Humanarum, 2014
This study aimed to identify and systemize what is being produced about the subject Fatherhood in Brazil, prioritizing topics such as: the researches’ methodology, the period and the place the researches were performed, and mainly, its content.
Juliana de Castro Prado, Jorge Luís Ferreira Abrão   +1 more
doaj   +1 more source

Reproductive Technologies and the Legal Determination of Fatherhood [PDF]

, 2005
In Re D is the most recent in a line of cases to have raised problems with the determination of legal fatherhood under s.28(3) of the Human Fertilisation and Embryology Act (1990).
Sheldon, S., Sally Sheldon, Sheldon, Sally   +2 more
core   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

“To Separate Myself from Them, I Think I Will Feel Great Sadness”: Transnational Fatherhood and Border Regimes in Central Mexico

Latin American Research Review
Studies of fatherhood in Latin America demonstrate an uneven shift from traditional, patriarchal fatherhood to a more reflexive version that incorporates elements of active, relational fatherhood.
Alison Elizabeth Lee, Mario Alberto Macías-Ayala   +1 more
doaj   +1 more source

Is fatherhood allowed? Media discourses of fatherhood in organizational life [PDF]

Gender, Work & Organization, 2019
It has been claimed that in the context of organizations and management, fathers are invisible. One source of tension for fathers who work and who want to participate in family life is that even though involved fatherhood is emerging in many western societies, a family‐oriented male identity is likely to be problematic for men in organizations.
Lämsä, Anna-Maija, Jyrkinen, Marjut, Kangas, Emilia   +3 more
openaire   +4 more sources

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source