Results 31 to 40 of about 875,896 (317)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Split sleeve cold expansion of AZ31B sheet: Microstructure, texture and residual stress

Materials & Design, 2020
Despite magnesium limited formability at room temperature, split sleeve hole cold expansion of AZ31B sheet was successfully implemented. Microstructural analysis showed greater hardness in the immediate vicinity of the notch, which was due to high ...
Sasan Faghih, Sugrib Kumar Shaha, Seyed Behzad Behravesh, Hamid Jahed   +3 more
doaj   +1 more source

The fatigue conundrum [PDF]

Brain, 2017
Fatigue is a major affective symptom in neurological disease, but its basis is poorly understood. Kuppuswamy describes the defining features of fatigue and its relationship to perceived effort, before proposing that pathological fatigue is a consequence of impaired sensory attenuation.
openaire   +4 more sources

Short fatigue questionnaire: Screening for severe fatigue. [PDF]

Journal of Psychosomatic Research, 2020
To determine psychometric properties, a cut-off score for severe fatigue and normative data for the 4-item Short Fatigue Questionnaire (SFQ) derived from the multi-dimensional fatigue questionnaire Checklist Individual Strength (CIS).Data of previous studies investigating the prevalence of fatigue in ten chronic conditions (n = 2985) and the general ...
Penson, Adriaan, van Deuren, Sylvia, Worm-Smeitink, Margreet, Bronkhorst, Ewald, van den Hoogen, Frank H.J., van Engelen, Baziel G.M., Peters, Marlies, Bleijenberg, Gijs, Vercoulen, Jan H., Blijlevens, Nicole, van Dulmen-den Broeder, Eline, Loonen, Jacqueline, Knoop, Hans   +12 more
openaire   +4 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

A continuous approach to explain insomnia and subjective-objective sleep discrepancy

Communications Biology
Understanding insomnia is crucial for improving its diagnosis and treatment. However, many subjective complaints about insomnia do not align with objective measures of sleep quality, as is the case in subjective-objective sleep discrepancy (SOSD).
Rubén Herzog, Flynn Crosbie, Anis Aloulou, Umaer Hanif, Mounir Chennaoui, Damien Léger, Thomas Andrillon   +6 more
doaj   +1 more source

Seismic Behavior of a Steel Beam-to-Concrete-Filled Steel Tubular Column Connection Using External Diaphragms

Applied Sciences, 2022
This paper investigates the seismic behavior of a steel beam-to-concrete-filled steel tubular column connection with external diaphragms. In addition to the multiple advantages observed for manufacturing and assembly, this type of connection is expected ...
Cristhian Ramirez Ortiz, Gilberto Areiza Palma, Albio D. Gutierrez Amador, Jose L. Ramirez Duque, Ruth E. Cano Buitron, Luis F. Gonzales Escobar   +5 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Thermomechanical Fatigue of Lost Foam Cast Al–Si Cylinder Heads—Assessment of Crack Origin Based on the Evaluation of Pore Distribution

Metals, 2019
In automotive cylinder heads, thermomechanical fatigue (TMF) leads to crack initiation within the critical loaded sections. This effect becomes even more relevant in lost foam cast cylinder heads since its system-dependent porosity shows a significant ...
Martin Wagner, Andreas Mösenbacher, Marion Eiber, Martin Hoyer, Marco Riva, Hans-Jürgen Christ   +5 more
doaj   +1 more source

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source