Results 31 to 40 of about 18,054 (268)

Multiaxial fatigue crack path prediction using critical plane concept [PDF]

Fracture and Structural Integrity, 2016
Prediction of fatigue crack orientation can be an essential step for estimating fatigue crack path. Critical plane concept is widely used due to its physical basis that fatigue failure is associated with certain plane(s). However, recent investigations
Jafar Albinmousa
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Predicting creep-fatigue crack growth rates in Alloy 709 using finite element simulations of plasticity and creep-induced crack closure

MATEC Web of Conferences, 2018
This paper reports on a computational study and experimental validation of creep-fatigue crack growth rates at high temperature in two structural materials.
Ramirez Jose, Potirniche Gabriel P., Pugesek Henry, Shaber Nicholas, Taylor Martin, Stephens Robert, Charit Indrajit   +6 more
doaj   +1 more source

Fatigue damage evaluation of 316LN stainless steel using acoustic emission monitoring

工程科学学报, 2018
The initiation and growth of fatigue cracks usually lead to serious fatigue failure of steel structures such as pressure vessels and pipelines. Therefore, for the safety and reliability of engineering structures, monitoring the fatigue crack growth and ...
ZHANG Jin, CHAI Meng-yu, XIANG Jing-hai, DUAN Quan   +3 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Study on Fracture Behavior of GH4169 Superalloy Considering Crack Closure Effect: Combining Numerical Modeling and BSL 3D DIC

Applied Sciences
As a critical aerospace structural material, the fatigue crack propagation behavior and fatigue life of the nickel-based GH4169 superalloy are directly related to the service safety of engineering components.
Zechang Li, Bin Kuang, Bin Wang, Xing Sun, Xinlong Yang, Bo Liu, Qihong Fang, Huimin Xie, Wei He, Yanhuai Ding   +9 more
doaj   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Modelling probabilistic fatigue crack propagation rates for a mild structural steel [PDF]

Fracture and Structural Integrity, 2015
A class of fatigue crack growth models based on elastic–plastic stress–strain histories at the crack tip region and local strain-life damage models have been proposed in literature.
J.A.F.O. Correia, A.M.P. de Jesus, A. Fernández-Canteli, R.A.B. Calçada   +3 more
doaj   +1 more source

Fatigue Crack Growth Under Random Overloads with Retardation

MATEC Web of Conferences, 2016
A Monte Carlo simulation scheme is presented to study the behavior of fatigue crack propagation under random overloads. Overloads of Poisson flow with uniform distribution on base-line constant-amplitude cyclic loads are considered.
Zou XiaoLi
doaj   +1 more source