Results 31 to 40 of about 161,024 (311)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Predicting creep-fatigue crack growth rates in Alloy 709 using finite element simulations of plasticity and creep-induced crack closure

MATEC Web of Conferences, 2018
This paper reports on a computational study and experimental validation of creep-fatigue crack growth rates at high temperature in two structural materials.
Ramirez Jose, Potirniche Gabriel P., Pugesek Henry, Shaber Nicholas, Taylor Martin, Stephens Robert, Charit Indrajit   +6 more
doaj   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, in collaboration with the Consensus Expert Panel (CEP) members, G. Alden Adkins, Brittany Adler, Hossein Ansari, Senada Arabelovic, Alan Baer, Denis Balaban, Shamik Bhattacharyya, Evelyn Bromet, Krishna Chaganti, Kamal Chemali, Melissa Cortez, Schartess Culpepper, Paul Dellaripa, Dana Direnzo, Daniel El Bogdadi, Robert Fearon, Mehrnez Fischbach, Judi Furlong, Christopher Gibbons, Rachael Gordon, Thomas Grader Beck, Syed Haider, Larry Hollenbeck, Chadwick R. Johr, Stuart S. Kassan, Brian King, Octavia Kincaid, Eugene Kissin, Vasileios Kyttaris, Lindsay Lally, Brandon M. Law, Janet Lewis, Scott M. Lieberman, Amanda Lusa, Joseph Lutt, Rashmi Maganti, Arthur M. Mandelin, Sara McCoy, Kerry Neall, Timothy Niewold, Anne Louise Oaklander, Ruben A. Peredo‐Wende, Lynn Petruzzi, Mark A. Porter, Guada Respicio Duque, Tania Reyna, Nathaniel M. Robbins, Elliot D. Rosenstein, Laura Rosow, Breanna Ruthrauff, Amit Sachdev, Nora Sandorfi, Sarah Schafer, Elena Schiopu, Chokkalingam Siva, Daniel Small, Sara M. Stern, Lauren Stiles, Susan Stoddard, Jinny Tavee, Donald Thomas, Edward L. Treadwell, Nagagopal Venna, Steven Vernino, Frederick B. Vivino, Brittany Weber, Sepideh Yadollahi, Huiying Yu, Scott Zashin   +88 more
wiley   +1 more source

Prediction of Fatigue Crack Growth in Vacuum-Brazed Titanium Alloy

Metals, 2023
The assessment of fatigue is a crucial concern in welded components and structures. This study investigates the fatigue properties and models for predicting fatigue crack growth in Ti-6Al-4V titanium alloy when processed by vacuum brazing with TiCuNi ...
Chou-Dian Huang, Jiun-Ren Hwang, Jiunn-Yuan Huang   +2 more
doaj   +1 more source

Characterization of crack nucleation in TA6V under fretting-fatigue loading using the potential drop technique [PDF]

, 2010
Crack initiation in a Ti-6Al-4V alloy was investigated experimentally in fretting fatigue conditions. A cylinder-plane geometry was used for the contact, and partial slip conditions were considered.
Andersson, Barnett, Fellows, Fouvry, Fouvry, Fouvry, Gandossi, Hutson, Johnson, Kondo, Kubota, Kubota, Lee, Lykins, Lykins, Madge, Mall, Martinez, Muñoz, Namjoshi, Navarro, Nelsen, Nicolaou, Nowell, Proudhon, Proudhon, Spitas, Szolwinski, Szolwinski, Venkatesh   +29 more
core   +2 more sources

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Study on Fracture Behavior of GH4169 Superalloy Considering Crack Closure Effect: Combining Numerical Modeling and BSL 3D DIC

Applied Sciences
As a critical aerospace structural material, the fatigue crack propagation behavior and fatigue life of the nickel-based GH4169 superalloy are directly related to the service safety of engineering components.
Zechang Li, Bin Kuang, Bin Wang, Xing Sun, Xinlong Yang, Bo Liu, Qihong Fang, Huimin Xie, Wei He, Yanhuai Ding   +9 more
doaj   +1 more source

Finite element analyses of fatigue crack growth under small scale yielding conditions modelled with a cyclic cohesive zone approach [PDF]

, 2013
Mode I fatigue crack growth is modelled and investigated with a cohesive zone approach. A 2D finite element boundary layer model under plane strain and small scale yielding conditions is used to generate fatigue crack growth rate curves ...
Kuna, Meinhard, Roth, Stephan
core  

Numerical Investigation of Fatigue Crack Propagation Behaviour of 550E High-Performance Steel

Metals, 2023
The fatigue crack propagation behaviour of Q550E high-performance steel (HPS) is studied in this paper. Static tensile testing and fatigue crack propagation testing were carried out, and the results were compared with those of Q235. Finite element models
Linfa Xiao, Heng Lin, Yongxiang Wang, Yiming Yang, Huapeng Chen   +4 more
doaj   +1 more source

High-resolution 3D weld toe stress analysis and ACPD method for weld toe fatigue crack initiation [PDF]

, 2019
Weld toe fatigue crack initiation is highly dependent on the local weld toe stress-concentrating geometry including any inherent flaws. These flaws are responsible for premature fatigue crack initiation (FCI) and must be minimised to maximise the fatigue
Chaudhuri, Somsubhro, Crump, J., Mellor, B. G., Reed, P. A. S.   +3 more
core   +2 more sources