Results 31 to 40 of about 18,134 (268)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Study on crack propagation of 42CrMo

Metalurgija, 2019
For the fatigue failure of 42CrMo, the tensile test was performed on the CT specimen at different load ratios using a fatigue tensile tester. Data on the fatigue crack growth rate of the material and the crack tip factor were obtained.
W. C. Pei, J. W. Dong, H. C. Ji, H. Y. Long, S. F. Yang   +4 more
doaj  

ON CRACK CLOSURE IN FATIGUE CRACK GROWTH

, 1978
A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire   +2 more sources

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Effect of grain structure on fatigue crack propagation behavior of 2024 aluminum alloy under different stress ratios

Materials & Design
The fatigue load that a material experiences and its microstructure are important factors influencing fatigue crack propagation behavior. This study employed laser scanning microscopy and electron backscatter diffraction (EBSD) technology, along with ...
Hongtao Chen, Shuyao Liu, Pai Wang, Xibin Wang, Zhibing Liu, Fadi Aldakheel   +5 more
doaj   +1 more source

On a kinked crack model to describe the influence of material microstructure on fatigue crack growth [PDF]

Fracture and Structural Integrity, 2013
Threshold condition and rate of fatigue crack growth in both short and long crack regime appear to be significantly affected by the degree of crack deflection.
Andrea Spagnoli, Andrea Carpinteri, Sabrina Vantadori   +2 more
doaj   +1 more source

Prediction of Fatigue Crack Growth in Vacuum-Brazed Titanium Alloy

Metals, 2023
The assessment of fatigue is a crucial concern in welded components and structures. This study investigates the fatigue properties and models for predicting fatigue crack growth in Ti-6Al-4V titanium alloy when processed by vacuum brazing with TiCuNi ...
Chou-Dian Huang, Jiun-Ren Hwang, Jiunn-Yuan Huang   +2 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source