Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian +9 more
wiley +1 more source
Fatigue assessment by energy approach during tensile tests on AISI 304 steel
Fracture and Structural Integrity, 2016 Estimation of the fatigue limit for steel ductile materials using non-destructive methods is a topic of great interest to researchers today. In recent years, the method adopted has implemented infrared sensors to detect the surface temperature and ...
A. Risitano +4 more
doaj
Fatigue damage in cross-ply titanium metal matrix composites containing center holes [PDF]
The development of fatigue damage in (0/90) sub SCS-6/TI-15-3 laminates containing center holes was studied. Stress levels required for crack initiation in the matrix were predicted using an effective strain parameter and compared to experimental results.
Bakuckas, J. G., Jr. +2 more
core +1 more source
Damage formation, fatigue behavior and strength properties of ZrO[2]-based ceramics [PDF]
, 2011 It is suggested that a non-destructive testing technique using a three-dimensional X-raytomography be applied to detecting internal structural defects and monitoring damage formation in a ceramic composite structure subjected to a bending load.
Kozulin, A. A. +4 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Rapid Assessment of the Fatigue Limit Using an Iterative Algorithm Applied to Intrinsic Dissipation
Engineering ProceedingsThe aim of this paper is to introduce and validate an iterative algorithm for the rapid assessment of the fatigue limit. The algorithm is based on the analysis of intrinsic dissipation and offers a more efficient alternative to traditional fatigue ...
Luca Santoro +2 more
doaj +1 more source
A new stress field intensity model and its application in component high cycle fatigue research.
PLoS ONE, 2020 Fatigue limit load is one of the most important and concerned factors in designing and manufacturing critical mechanical parts such as the crankshafts.
SongSong Sun
doaj +1 more source
Influence of Loading Frequency on Fatigue Properties of Structural Materials [PDF]
, 2008 Tato práce se zabývá vlivem frekvence zatěžování na únavu konstrukčních materiálů. Nízkofrekvenční zatěžování (do 200 Hz) nemá ve většině případů na únavové vlastnosti vliv.
Kašpar, Jan
core
Non-local energy based fatigue life calculation method under multiaxial variable amplitude loadings [PDF]
, 2013 Reliable design of industrial components against high cycle multiaxial fatigue requires a model capable of predicting both stress gradient and load type effects. Indeed, taking into account gradient effects is of prior importance for the applicability of
BÉNABÈS, Jérôme +3 more
core +6 more sources
Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein +13 more
wiley +1 more source