Results 51 to 60 of about 514,365 (308)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Experimental investigation of surface roughness effect on fatigue performance of AISI 1045 carbon steel and fatigue limit prediction

Fracture and Structural Integrity, 2019
In fatigue life, surface integrity perform a major role to determine the fatigue lifetime. It could differ greatly among specific cases even for the same solicitations.
Khadija Kimakh, Abdelkerim Chouaf, Amal Saoud, El Hassan Mallil, Samir Aghzer   +4 more
doaj   +3 more sources

Fatigue Limit Estimation Based on Dissipated Energy of Butt Laser-Welded Joints

Engineering Proceedings
This study established a rapid estimation method for the fatigue limit of laser welds of aluminum alloys in order to optimize welding conditions, an important factor in ensuring the safety and reliability of laser welding.
Takumi Yamamoto, Yuki Ogawa, Miu Hayashi, Kota Kadoi, Daiki Shiozawa, Takahide Sakagami   +5 more
doaj   +1 more source

Effect of orientation of small defects on fatigue limit of steels

MATEC Web of Conferences, 2014
In order to clarify the effect of defect orientation on the fatigue limit of three types of steels; JIS-S15C, JIS-S45C and JIS-SNCM439, a small semi-circular slit was introduced into the surface of a round specimen. The slits were tilted at 0∘, 30∘ or 60∘
Lorenzino Pablo, Okazaki Saburo, Matsunaga Hisao, Murakami Yukitaka   +3 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

PREDICTION OF FATIGUE LIFE BASED ON FUZZY MATHEMATICS AND GREY SYSTEM THEORY

Jixie qiangdu, 2023
The traditional fatigue life prediction method Miner theory ignored the damage caused by stress below the fatigue limit to the component, resulting in a large error in fatigue life prediction.
XU RongXia, GAO JianXiong, WU ZhiFeng, ZHU PengNian   +3 more
doaj  

Study on Fatigue Life of Fractured Rock Under Constant Amplitude Cyclic Loading

Earth Sciences Research Journal, 2018
The electro-hydraulic servo loading system was applied to make cyclic loading tests for fractured rock-like specimens. According to the results of the fatigue test, the power function model was used to fit and analyze the test data, and the fitting ...
Run Li, Wenbin Jian, Rongtao Kang
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Fatigue life prediction of austenitic Type 316L stainless steel using ABAQUS [PDF]

, 2014
This work has carried out on Type 316L stainless steel of hollow bar specimen. The aim of this work is to determine the fatigue life prediction using Finite Element Analysis (FEA). The simulation performed by applied the different stress level to predict
Ali, Aidy, Mohammad, Khairul Azhar, Salit, Mohd Sapuan, Zahari, Nur Ismarubie, Zainudin, Edi Syams   +4 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source