Results 41 to 50 of about 386 (199)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Avaliação de métodos indiretos de determinação da erodibilidade de Latossolos brasileiros

Pesquisa Agropecuária Brasileira, 2000
Existem três maneiras de se determinar a erodibilidade do solo (Fator K). A primeira envolve a determinação do fator K em condições de campo, sob chuva natural, a qual é onerosa e muito demorada. O segundo método é semelhante ao primeiro, porém baseia-se
SILVA MARX LEANDRO NAVES, CURI NILTON, LIMA JOSÉ MARIA DE, FERREIRA MOZART MARTINS   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Carga parasitária de Rondonia rondoni, Travassos, 1920 (Nematoda, Atrictidae) e fator de condição do armado, Pterodoras granulosus, Valenciennes, 1833 (Pisces, Doradidae) - DOI: 10.4025/actascibiolsci.v26i2.1613

Acta Scientiarum: Biological Sciences, 2008
Objetiva-se avaliar o efeito da carga parasitária de Rondonia rondoni sobre o fator de condição de armados, Pterodoras granulosus. Foram necropsiados 51 espécimes de armados, coletados no rio Paraná (Porto Rico/Paraná). Para as análises, utilizaram-se os
Priscila Gôngora Dias, Wilson Massamitu Furuya, Gilberto Cezar Pavanelli, Marion Haruko Machado, Ricardo Massato Takemoto   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Vulnerabilidade natural: a perda de solo da bacia do rio Carinhanha (MG/BA) usando uma abordagem qualitativa da equação universal de perda de solos

Revista Geographia, 2013
O objetivo deste trabalho foi mapear e analisar a susceptibilidade erosiva da bacia do rio Carinhanha por meio da aplicação da Equação Universal de Perda de Solo (EUPS), a fim de subsidiar o planejamento territorial ambiental na área.
Kelly Maria Resende Borges, Osmar Abilio Carvalho Júnior, Eder Souza Martins, Roberto Arnaldo Trancoso Gomes, Renato Fontes Guimarães   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

RELAÇÃO ENTRE PARÂMETROS DA CHUVA E PERDAS DE SOLO E DETERMINAÇÃO DA ERODIBILIDADE DE UM LATOSSOLO VERMELHO-ESCuro EM GOIÂNIA (GO) [PDF]

Revista Brasileira de Ciência do Solo
RESUMO A erodibilidade do solo, que representa sua suscetibilidade à erosão, é expressa pelo fator K da equação universal de perda de solo. No Brasil, ainda são relativamente poucos os trabalhos envolvendo estudos de erodibilidade do solo, dada a ...
M. L. N. SILVA, P. L. FREITAS, P. BLANCANEAUX, N. CURI, J. M. LIMA   +4 more
doaj   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source