Results 61 to 70 of about 377 (198)
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Com o intuito de investigar a alocação de energia e a correlação entre esta e o fator de condição (K) de peixes da planície de inundação do alto rio Paraná (22º43’S; 53º32’W), foram selecionadas as espécies Serrasalmus marginatus (piscívora ...
Melina Rizzato Vismara +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
DETERMINAÇÃO E ESPACIALIZAÇÃO DA PERDA DE SOLO DA BACIA HIDROGRÁFICA DO CÓRREGO CASCAVEL, GOIÁS
O modelo de predição de erosão hídrica baseado na Equação Universal de Perda de Solo (USLE), bem como suas variações, tem sido amplamente empregado no Brasil e no mundo devido sua robustez e eficiência.
Tatiane Souza Rodrigues Pereira +3 more
doaj +3 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ESTIMATIVA DA ERODIBILIDADE DO SOLO PELO MÉTODO INDIRETO
Objetivou-se avaliar a erodibilidade do solo pelo método indireto, baseado nas porcentagens de frações de areia, silte e argila, para quatro classes de solos de alguns municípios localizados no estado do Espírito Santo.
Dione Cardoso, Fábio Pires
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Neste trabalho são apresentados os resultados da análise quantitativa aplicada a dados obtidos em experimento de policultivo semi-intensivo efetuado com as espécies Cyprinus carpio L., 1758, Prochilodus cearensis Steindachner, 1911 e Colossoma ...
Maria de Fátima Pereira de SÁ +2 more
doaj

