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Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Analysis of sarcopenia parameters and falls in hemodialysis patients: no association found in a cross-sectional study. [PDF]

J Bras Nefrol
Oblanca JV, Reichert TL, Faúndez-Casanova C, Marchini KB, Torres F, Ardengue M, Yamada SS, Avelar A.   +7 more
europepmc   +1 more source

Speech therapy program for the rehabilitation of smell. [PDF]

Codas
César CPHAR, Lima KM, Oliveira OMS, Santos LMN, Dantas VS, Domenis DR, Cavalcante RCM, Guedes-Granzotti RB, Silva KD.   +8 more
europepmc   +1 more source

Prevalence and factors associated with self-medication among schoolchildren in the Metropolitan Region of Vitória, Brazil. [PDF]

Rev Esc Enferm USP
Mairink KR, Miguez FGG, Lopes CA, Camboin FF, Santana NMT, Pereira NBR, Leite FMC.   +6 more
europepmc   +1 more source

Are Your kidneys ok? Detect early to protect kidney health. [PDF]

J Bras Nefrol
Vassalotti JA, Francis A, Santos ACSD, Correa-Rotter R, Abdellatif D, Hsiao LL, Roumeliotis S, Haris A, Kumaraswami LA, Lui SF, Balducci A, Liakopoulos V.   +11 more
europepmc   +1 more source

Reliability between measurements obtained by caliper and digital photography in facial anthropometry. [PDF]

Codas
Andrade RSS, Matos PVOS, Rehder MIBC, Guedes-Granzotti RB, Silva KD, César CPHAR.   +5 more
europepmc   +1 more source

Effect of lifestyle modification and atorvastatin on dyslipidemia and endothelial dysfunction markers in children with steroid resistant nephrotic syndrome. [PDF]

J Bras Nefrol
Kakkar V, Saha A, Agrawal P, Sharma S, Nagia A, Singh P, Pemde HK.   +6 more
europepmc   +1 more source

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A IMPORTÂNCIA DA VITAMINA K COMO FATOR DE PREVENÇÃO PARA DISTÚRBIOS ADQUIRIDOS DA HEMOSTASIA.

Anais do II Congresso Brasileiro de Hematologia Clínico-laboratorial On-line, 2022
Introdução: A hemostasia baseia-se no mecanismo de bloqueio de uma ruptura vascular, o que garante a integridade desses vasos por meio dos fatores da coagulação sanguínea. Algumas alterações nos fatores de coagulação podem acarretar distúrbios que comprometam o processo de coagulação e consequentemente a hemostasia vascular, como a deficiência da ...
Thaiane Fernanda Marques Barros Bezerra, Eduarda Erika Ursulino Matos, Silvana Maria De Morais Campos, Carla Mikaela Brandão Santos, Waleska Mendonça Paes Silva   +4 more
openaire   +1 more source