Results 51 to 60 of about 1,369 (247)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

AJUSTE DO FATOR K NO DOBRAMENTO DE CHAPAS METÁLICAS: REVISÃO CRÍTICA E PROPOSTA DE MODELO BASEADO EM VARIÁVEIS FÍSICO-QUÍMICAS

Revista DCS
O dobramento de chapas metálicas é um processo amplamente utilizado na indústria, no qual o controle preciso de parâmetros como o fator K é fundamental para garantir qualidade dimensional e minimizar desperdícios. Este artigo apresenta uma revisão sistemática da literatura sobre métodos de previsão de retorno elástico (springback) e estratégias de ...
Fábio Lodi, Lisiane Trevisan, Paulo Janissek, Juliano Cantarelli Toniolo   +3 more
openaire   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Efeito da maturação gonadal sobre o conteúdo calórico e condição geral de peixes da planície de inundação do alto rio Paraná - DOI: 10.4025/actascibiolsci.v26i2.1635

Acta Scientiarum: Biological Sciences, 2008
Com o intuito de investigar a alocação de energia e a correlação entre esta e o fator de condição (K) de peixes da planície de inundação do alto rio Paraná (22º43’S; 53º32’W), foram selecionadas as espécies Serrasalmus marginatus (piscívora ...
Melina Rizzato Vismara, Evanilde Benedito-Cecilio, Anna Christina Esper Amaro de Faria   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

DETERMINAÇÃO E ESPACIALIZAÇÃO DA PERDA DE SOLO DA BACIA HIDROGRÁFICA DO CÓRREGO CASCAVEL, GOIÁS

Revista Geográfica Acadêmica, 2015
O modelo de predição de erosão hídrica baseado na Equação Universal de Perda de Solo (USLE), bem como suas variações, tem sido amplamente empregado no Brasil e no mundo devido sua robustez e eficiência.
Tatiane Souza Rodrigues Pereira, Kamila Almeida dos Santos, Bruna Ferreira da Silva, Klebber Teodomiro Martins Formiga   +3 more
doaj   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

ESTIMATIVA DA ERODIBILIDADE DO SOLO PELO MÉTODO INDIRETO

Revista UniVap, 2017
Objetivou-se avaliar a erodibilidade do solo pelo método indireto, baseado nas porcentagens de frações de areia, silte e argila, para quatro classes de solos de alguns municípios localizados no estado do Espírito Santo.
Dione Cardoso, Fábio Pires
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source