Results 231 to 240 of about 14,521,232 (278)

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Health and disability assessment in individuals with hearing loss: a longitudinal study using WHODAS 2.0. [PDF]

Codas
Santos KMGD, Dias RCT, Silva JLAMP, Nascimento GFFD.   +3 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Estratégia de controle para o conversor duplo boost operando em condução contínua aplicado na correção do fator de potência [PDF]

, 1995
Martins, Alexandre Saccol
core  

Water quality dynamics in urban river of the semiarid region under anthropogenic pressure: a spatiotemporal analysis in the stretch of the municipality of Mossoró (Brazil). [PDF]

Environ Monit Assess
da Silva ALS, Bezerra HN, Farias PKP, da Silva MSM, Costa LKO, da Silva LVM, de Oliveira Batista CN, da Costa Leite Coelho D, de Mesquita Arruda MV, de Sousa Antunes LF, Batista RO.   +10 more
europepmc   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Prevalence and factors associated with severe pain in the postoperative period of orthopedic surgery. [PDF]

Rev Bras Enferm
Almeida JC, Kamide TV, Miura CRM.
europepmc   +1 more source

Is Female Gender Associated with Mortality in Coronary Artery Bypass Grafting? [PDF]

Arq Bras Cardiol
Goncharov M, Silva EOA, Silva PGMBE, Freitas FL, Moreira AC, Tramujas L, Cavalcanti AB, Liguori IM, Jatene FB, Jatene IB, Alves CMR.   +10 more
europepmc   +1 more source